(Z)-benzyl 4-(4-(2-oxooxazolidin-3-yl)-4-((trimethylsilyl)oxy)but-3-en-1-yl)piperidine-1-carboxylate

Base Information

Chemical Name:(Z)-benzyl 4-(4-(2-oxooxazolidin-3-yl)-4-((trimethylsilyl)oxy)but-3-en-1-yl)piperidine-1-carboxylate
CAS No.:1330681-24-7
Molecular Formula:C₂₃H₃₄N₂O₅Si
Molecular Weight:446.619
Hs Code.:

Synonyms:(Z)-benzyl 4-(4-(2-oxooxazolidin-3-yl)-4-((trimethylsilyl)oxy)but-3-en-1-yl)piperidine-1-carboxylate

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Chemical Property of (Z)-benzyl 4-(4-(2-oxooxazolidin-3-yl)-4-((trimethylsilyl)oxy)but-3-en-1-yl)piperidine-1-carboxylate

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Technology Process of (Z)-benzyl 4-(4-(2-oxooxazolidin-3-yl)-4-((trimethylsilyl)oxy)but-3-en-1-yl)piperidine-1-carboxylate

There total 1 articles about (Z)-benzyl 4-(4-(2-oxooxazolidin-3-yl)-4-((trimethylsilyl)oxy)but-3-en-1-yl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: benzyl 4-(4-chloro-4-oxobutyl)piperidine-1-carboxylate

: 1330681-24-7
(Z)-benzyl 4-(4-(2-oxooxazolidin-3-yl)-4-((trimethylsilyl)oxy)but-3-en-1-yl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.25 h / -78 °C / Inert atmosphere

1.2: 1.5 h / -78 - 20 °C / Inert atmosphere

2.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

2.2: 1 h / -78 - 20 °C / Inert atmosphere

With n-butyllithium; sodium hexamethyldisilazane; In tetrahydrofuran; hexane;
DOI:10.1021/ja206047h

Reference yield: 96.0%

: 1204518-00-2
(4-chlorophenyl)(mesityl)iodonium trifluoromethanesulfonate

: 1330681-24-7
(Z)-benzyl 4-(4-(2-oxooxazolidin-3-yl)-4-((trimethylsilyl)oxy)but-3-en-1-yl)piperidine-1-carboxylate

: 1330681-54-3
(R)-benzyl 4-(3-(4-chlorophenyl)-4-oxo-4-(2-oxooxazolidin-3-yl)butyl)piperidine-1-carboxylate

Guidance literature:: With [Cu(OTf)2((R)-Ph-BOX)]; In dichloromethane; at 20 ℃; for 2h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;
DOI:10.1021/ja206047h

Reference yield: 95.0%

: 1330681-24-7
(Z)-benzyl 4-(4-(2-oxooxazolidin-3-yl)-4-((trimethylsilyl)oxy)but-3-en-1-yl)piperidine-1-carboxylate

: 144930-50-7
mesityl(phenyl)iodonium triflouromethanesulfonate

: 1330681-37-2
(R)-benzyl 4-(4-oxo-4-(2-oxooxazolidin-3-yl)-3-phenylbutyl)piperidine-1-carboxylate

Guidance literature:: With [Cu(OTf)2((R)-Ph-BOX)]; In dichloromethane; at 20 ℃; for 2h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;
DOI:10.1021/ja206047h