(S)-1-(4-(2-(p-methylphenylsulfonyloxy)ethoxy)benzyl)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin

Base Information

• Chemical Name: (S)-1-(4-(2-(p-methylphenylsulfonyloxy)ethoxy)benzyl)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin
• CAS No.: 899818-44-1
• Molecular Formula: C₃₀H₃₂N₂O₉S₂
• Molecular Weight: 628.724
• Mol file: 899818-44-1.mol

Synonyms:(S)-1-(4-(2-(p-methylphenylsulfonyloxy)ethoxy)benzyl)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin

Chemical Property of (S)-1-(4-(2-(p-methylphenylsulfonyloxy)ethoxy)benzyl)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-1-(4-(2-(p-methylphenylsulfonyloxy)ethoxy)benzyl)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin

There total 11 articles about (S)-1-(4-(2-(p-methylphenylsulfonyloxy)ethoxy)benzyl)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

(S)-1-(4-(2-bromoethoxy)benzyl)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin (899818-43-0) + silver(I) 4-methylbenzenesulfonate (16836-95-6) → (S)-1-(4-(2-(p-methylphenylsulfonyloxy)ethoxy)benzyl)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin (899818-44-1)

Guidance literature:

In acetonitrile; for 24h; Heating;

DOI:10.1021/jm051217c

Reference yield:

(2S)-2-(methoxymethyl)-1-pyrrolidine (63126-47-6) → (S)-1-(4-(2-(p-methylphenylsulfonyloxy)ethoxy)benzyl)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin (899818-44-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 2.05 g / N,N-diisopropylethylamine / tetrahydrofuran; CHCl₃ / 0.5 h

2.1: NaH / dimethylformamide / 0.5 h / 20 °C

2.2: 77 percent / dimethylformamide / 20 °C

3.1: 94 percent / acetonitrile / 24 h / Heating

With sodium hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; chloroform; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1021/jm051217c

Reference yield:

1-(2-bromoethoxy)-4-(bromomethyl)benzene (899818-28-1) → (S)-1-(4-(2-(p-methylphenylsulfonyloxy)ethoxy)benzyl)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin (899818-44-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: NaH / dimethylformamide / 0.5 h / 20 °C

1.2: 77 percent / dimethylformamide / 20 °C

2.1: 94 percent / acetonitrile / 24 h / Heating

With sodium hydride; In N,N-dimethyl-formamide; acetonitrile;

DOI:10.1021/jm051217c

upstream raw materials:

(S)-1-(4-(2-bromoethoxy)benzyl)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin

silver(I) 4-methylbenzenesulfonate

1-(2-bromoethoxy)-4-(bromomethyl)benzene

2-methoxymethylpyrrolidine-1-carboxylic acid tert-butyl ester

Downstream raw materials:

(S)-1-(4-(2-[18F]fluoroethoxy)benzyl)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin