4-oxo-pentanoic acid 1-({6-[3-benzyloxy-5-(3-benzyloxy-hexadecanoylamino)-4-hydroxy-6-phenylsulfanyl-tetrahydro-pyran-2-ylmethoxy]-8-hydroxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-ylcarbamoyl}-methyl)-tetradecyl ester

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Chemical Name:4-oxo-pentanoic acid 1-({6-[3-benzyloxy-5-(3-benzyloxy-hexadecanoylamino)-4-hydroxy-6-phenylsulfanyl-tetrahydro-pyran-2-ylmethoxy]-8-hydroxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-ylcarbamoyl}-methyl)-tetradecyl ester
CAS No.:775341-79-2
Molecular Formula:C₇₆H₁₁₀N₂O₁₄S
Molecular Weight:1307.78
Hs Code.:

4-oxo-pentanoic acid 1-({6-[3-benzyloxy-5-(3-benzyloxy-hexadecanoylamino)-4-hydroxy-6-phenylsulfanyl-tetrahydro-pyran-2-ylmethoxy]-8-hydroxy-2-phenyl-hexahydro-pyrano[3,2-<i>d</i>][1,3]dioxin-7-ylcarbamoyl}-methyl)-tetradecyl ester

Synonyms:4-oxo-pentanoic acid 1-({6-[3-benzyloxy-5-(3-benzyloxy-hexadecanoylamino)-4-hydroxy-6-phenylsulfanyl-tetrahydro-pyran-2-ylmethoxy]-8-hydroxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-ylcarbamoyl}-methyl)-tetradecyl ester

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Chemical Property of 4-oxo-pentanoic acid 1-({6-[3-benzyloxy-5-(3-benzyloxy-hexadecanoylamino)-4-hydroxy-6-phenylsulfanyl-tetrahydro-pyran-2-ylmethoxy]-8-hydroxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-ylcarbamoyl}-methyl)-tetradecyl ester

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Technology Process of 4-oxo-pentanoic acid 1-({6-[3-benzyloxy-5-(3-benzyloxy-hexadecanoylamino)-4-hydroxy-6-phenylsulfanyl-tetrahydro-pyran-2-ylmethoxy]-8-hydroxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-ylcarbamoyl}-methyl)-tetradecyl ester

There total 10 articles about 4-oxo-pentanoic acid 1-({6-[3-benzyloxy-5-(3-benzyloxy-hexadecanoylamino)-4-hydroxy-6-phenylsulfanyl-tetrahydro-pyran-2-ylmethoxy]-8-hydroxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-ylcarbamoyl}-methyl)-tetradecyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 775341-78-1
phenyl 2-amino-4-O-benzyl-6-O-{4,6-O-benzylidene-2-deoxy-2-[(R)-3-levulinoyloxyhexadecanoylamino]-β-D-glucopyranosyl}-2-deoxy-1-thio-α-D-glucopyranoside

: 548486-16-4
(R)-3-(benzyloxy)hexadecanoic acid

: 775341-79-2
4-oxo-pentanoic acid 1-({6-[3-benzyloxy-5-(3-benzyloxy-hexadecanoylamino)-4-hydroxy-6-phenylsulfanyl-tetrahydro-pyran-2-ylmethoxy]-8-hydroxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-ylcarbamoyl}-methyl)-tetradecyl ester

Guidance literature:: With dicyclohexyl-carbodiimide; In dichloromethane; for 16h;
DOI:10.1021/ol048746f

Reference yield:

: 2-(4-bromophenyl)-2-oxoethyl (R)-3-hydroxyhexadecanoate

: 775341-79-2
4-oxo-pentanoic acid 1-({6-[3-benzyloxy-5-(3-benzyloxy-hexadecanoylamino)-4-hydroxy-6-phenylsulfanyl-tetrahydro-pyran-2-ylmethoxy]-8-hydroxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-ylcarbamoyl}-methyl)-tetradecyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 80 percent / hexamethyldisiloxane; TMSOTf; triethylsilane / tetrahydrofuran / 2 h

2: 64 percent / zinc / acetic acid / 2 h / 60 °C

3: 78 percent / dicyclohexylcarbodiimide / CH₂Cl₂ / 16 h

With triethylsilane; Hexamethyldisiloxane; trimethylsilyl trifluoromethanesulfonate; dicyclohexyl-carbodiimide; zinc; In tetrahydrofuran; dichloromethane; acetic acid;
DOI:10.1021/ol048746f

Reference yield:

: 775341-76-9
(R)-3-levulinoyloxyhexadecanoic acid

: 775341-79-2
4-oxo-pentanoic acid 1-({6-[3-benzyloxy-5-(3-benzyloxy-hexadecanoylamino)-4-hydroxy-6-phenylsulfanyl-tetrahydro-pyran-2-ylmethoxy]-8-hydroxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-ylcarbamoyl}-methyl)-tetradecyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / dicyclohexylcarbodiimide / CH₂Cl₂ / 16 h / 20 °C

2: 71 percent / triethylamine; propanedithiol / pyridine; H₂O / 16 h / 20 °C

3: 78 percent / dicyclohexylcarbodiimide / CH₂Cl₂ / 16 h

With 1,2-propanedithiol; triethylamine; dicyclohexyl-carbodiimide; In pyridine; dichloromethane; water;
DOI:10.1021/ol048746f