Technology Process of (2R,3R,11bR)-9-(benzyloxy)-3-isobutyl-10-methoxy-2,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-ol
There total 16 articles about (2R,3R,11bR)-9-(benzyloxy)-3-isobutyl-10-methoxy-2,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-ol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
9-(benzyloxy)-3-isobutyl-10-methoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-ol di-p-toluoyl-L-tartrate;
In
acetone;
With
ammonium hydroxide;
In
dichloromethane; water;
pH=10;
DOI:10.1080/00397911.2019.1663539
- Guidance literature:
-
Multi-step reaction with 6 steps
1: ammonium acetate; acetic acid / Reflux
2: lithium aluminium tetrahydride
3: acetic acid; trifluoroacetic acid
4: N-benzyl-N,N,N-triethylammonium chloride / water / 6 h / 95 °C
5: sodium tetrahydroborate / ethanol / 12 h
6: Di-p-toluoyl-L-tartaric acid
With
sodium tetrahydroborate; lithium aluminium tetrahydride; Di-p-toluoyl-L-tartaric acid; ammonium acetate; N-benzyl-N,N,N-triethylammonium chloride; acetic acid; trifluoroacetic acid;
In
ethanol; water;
DOI:10.1002/chir.22126
- Guidance literature:
-
Multi-step reaction with 4 steps
1: acetic acid; trifluoroacetic acid
2: N-benzyl-N,N,N-triethylammonium chloride / water / 6 h / 95 °C
3: sodium tetrahydroborate / ethanol / 12 h
4: Di-p-toluoyl-L-tartaric acid
With
sodium tetrahydroborate; Di-p-toluoyl-L-tartaric acid; N-benzyl-N,N,N-triethylammonium chloride; acetic acid; trifluoroacetic acid;
In
ethanol; water;
DOI:10.1002/chir.22126
![9-(benzyloxy)-3-isobutyl-10-methoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-ol di-p-toluoyl-L-tartrate](/Databaselist/images/loading.webp)
