ethyl 6-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-4-methyl-2-quinazolinecarboxylate

Base Information

Chemical Name:ethyl 6-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-4-methyl-2-quinazolinecarboxylate
CAS No.:1020577-05-2
Molecular Formula:C₃₁H₂₇Cl₂N₃O₄
Molecular Weight:576.479
Hs Code.:

Synonyms:ethyl 6-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-4-methyl-2-quinazolinecarboxylate

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Chemical Property of ethyl 6-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-4-methyl-2-quinazolinecarboxylate

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Technology Process of ethyl 6-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-4-methyl-2-quinazolinecarboxylate

There total 4 articles about ethyl 6-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-4-methyl-2-quinazolinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1020576-98-0
ethyl 6-bromo-4-methyl-2-quinazolinecarboxylate

: 1020576-09-3
3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-({[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]oxy}methyl)isoxazole

: 1020577-05-2
ethyl 6-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-4-methyl-2-quinazolinecarboxylate

Guidance literature:: With potassium phosphate; palladium diacetate; triphenylphosphine; In 1,4-dioxane; water; at 60 ℃; for 14h;

Reference yield:

: 1020576-91-3
ethyl 2-((2-acetyl-4-bromophenyl)amino)-2-oxoacetate

: 1020577-05-2
ethyl 6-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-4-methyl-2-quinazolinecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: ammonium acetate / acetic acid / 19 h / Reflux

2: potassium phosphate; palladium diacetate; triphenylphosphine / 1,4-dioxane; water / 14 h / 60 °C

With potassium phosphate; ammonium acetate; palladium diacetate; triphenylphosphine; In 1,4-dioxane; water; acetic acid; 2: Suzuki coupling;
DOI:10.1016/j.bmcl.2010.12.089

Reference yield:

: 41877-24-1
1-(5-bromo-2-nitrophenyl)ethane-1-one

: 1020577-05-2
ethyl 6-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-4-methyl-2-quinazolinecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: tin(ll) chloride; zinc(II) chloride / diethyl ether; ethanol / 3 h / 70 °C / Molecular sieve; Inert atmosphere

2: pyridine / dichloromethane / 17 h / 0 - 25 °C / Inert atmosphere

3: ammonium acetate / acetic acid / 19 h / Reflux

4: potassium phosphate; palladium diacetate; triphenylphosphine / 1,4-dioxane; water / 14 h / 60 °C

With pyridine; potassium phosphate; ammonium acetate; palladium diacetate; triphenylphosphine; tin(ll) chloride; zinc(II) chloride; In 1,4-dioxane; diethyl ether; ethanol; dichloromethane; water; acetic acid; 4: Suzuki coupling;
DOI:10.1016/j.bmcl.2010.12.089