3-(4-methoxyphenyl)-5-methyl-[1,2,3]triazolo[1,5-a]quinoxalin-4(5H)-one

Base Information

Chemical Name:3-(4-methoxyphenyl)-5-methyl-[1,2,3]triazolo[1,5-a]quinoxalin-4(5H)-one
CAS No.:1359822-19-7
Molecular Formula:C₁₇H₁₄N₄O₂
Molecular Weight:306.324
Hs Code.:

Synonyms:3-(4-methoxyphenyl)-5-methyl-[1,2,3]triazolo[1,5-a]quinoxalin-4(5H)-one

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Chemical Property of 3-(4-methoxyphenyl)-5-methyl-[1,2,3]triazolo[1,5-a]quinoxalin-4(5H)-one

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Technology Process of 3-(4-methoxyphenyl)-5-methyl-[1,2,3]triazolo[1,5-a]quinoxalin-4(5H)-one

There total 4 articles about 3-(4-methoxyphenyl)-5-methyl-[1,2,3]triazolo[1,5-a]quinoxalin-4(5H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1310372-74-7
N-(2-Iodophenyl)-3-(4-methoxyphenyl)-N-methylpropiolamide

: 1359822-19-7
3-(4-methoxyphenyl)-5-methyl-[1,2,3]triazolo[1,5-a]quinoxalin-4(5H)-one

: C₁₇H₁₅IN₄O₂

Guidance literature:: With copper(l) iodide; sodium azide; In dimethyl sulfoxide; at 90 ℃; for 24h; Inert atmosphere;
DOI:10.1021/ol300114w

Reference yield: 78.0%

: 1310372-74-7
N-(2-Iodophenyl)-3-(4-methoxyphenyl)-N-methylpropiolamide

: 1359822-19-7
3-(4-methoxyphenyl)-5-methyl-[1,2,3]triazolo[1,5-a]quinoxalin-4(5H)-one

Guidance literature:: With sodium azide; In dimethyl sulfoxide; at 130 ℃; for 12h; Schlenk technique;
DOI:10.1021/acs.joc.0c02022

Reference yield:

: 615-43-0
2-iodophenylamine

: 1359822-19-7
3-(4-methoxyphenyl)-5-methyl-[1,2,3]triazolo[1,5-a]quinoxalin-4(5H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 20 °C / Schlenk technique

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere; Schlenk technique

2.2: 2 h / -40 °C / Inert atmosphere; Schlenk technique

2.3: 20 °C / Inert atmosphere; Schlenk technique

3.1: sodium azide / dimethyl sulfoxide / 12 h / 130 °C / Schlenk technique

With n-butyllithium; sodium azide; triethylamine; In tetrahydrofuran; hexane; dichloromethane; dimethyl sulfoxide;
DOI:10.1021/acs.joc.0c02022