(S)-6-bromo-N-(3-(1-methyl-1H-pyrazol-4-yl)-5-(1-methylpyrrolidin-3-yloxy)phenyl)quinazolin-2-amine

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Chemical Name:(S)-6-bromo-N-(3-(1-methyl-1H-pyrazol-4-yl)-5-(1-methylpyrrolidin-3-yloxy)phenyl)quinazolin-2-amine
CAS No.:1202035-97-9
Molecular Formula:C₂₃H₂₃BrN₆O
Molecular Weight:479.379
Hs Code.:

Synonyms:(S)-6-bromo-N-(3-(1-methyl-1H-pyrazol-4-yl)-5-(1-methylpyrrolidin-3-yloxy)phenyl)quinazolin-2-amine

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Chemical Property of (S)-6-bromo-N-(3-(1-methyl-1H-pyrazol-4-yl)-5-(1-methylpyrrolidin-3-yloxy)phenyl)quinazolin-2-amine

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Technology Process of (S)-6-bromo-N-(3-(1-methyl-1H-pyrazol-4-yl)-5-(1-methylpyrrolidin-3-yloxy)phenyl)quinazolin-2-amine

There total 8 articles about (S)-6-bromo-N-(3-(1-methyl-1H-pyrazol-4-yl)-5-(1-methylpyrrolidin-3-yloxy)phenyl)quinazolin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₃H₂₁BrN₆O

: 1202035-97-9
(S)-6-bromo-N-(3-(1-methyl-1H-pyrazol-4-yl)-5-(1-methylpyrrolidin-3-yloxy)phenyl)quinazolin-2-amine

Guidance literature:: C₂₃H₂₁BrN₆O; With sodium triacetoxy borohydride; In methanol; water; for 0.5h;

With water; In methanol;

Reference yield:

: 16618-67-0
3-bromo-5-nitroanisole

: 1202035-97-9
(S)-6-bromo-N-(3-(1-methyl-1H-pyrazol-4-yl)-5-(1-methylpyrrolidin-3-yloxy)phenyl)quinazolin-2-amine

Guidance literature:: Multi-step reaction with 8 steps

1.1: boron tribromide / dichloromethane / 20 °C / Cooling with ice bath

1.2: -78 - 20 °C

2.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / tetrahydrofuran; water / 1.5 h / 80 °C

3.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0.33 h / 20 °C

3.2: 15 h

4.1: hydrogen / palladium 10% on activated carbon / methanol / 17 h / 20 °C / 760.05 Torr / Inert atmosphere of argon

5.1: isopropyl alcohol / 16 h / 100 °C

6.1: trifluoroacetic acid / dichloromethane / 0.25 h

6.2: pH ~ 11

7.1: acetic acid / methanol; water / 0.75 h / 20 °C

8.1: sodium triacetoxy borohydride / methanol; water / 0.5 h

With sodium triacetoxy borohydride; hydrogen; boron tribromide; sodium carbonate; triphenylphosphine; trifluoroacetic acid; diethylazodicarboxylate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; acetic acid; In tetrahydrofuran; methanol; dichloromethane; water; isopropyl alcohol; 2.1: Suzuki Coupling / 3.1: Mitsunobu reaction / 3.2: Mitsunobu reaction;

Reference yield:

: 1036756-65-6
3-(1-methyl-1H-pyrazol-4-yl)-5-nitrophenol

: 1202035-97-9
(S)-6-bromo-N-(3-(1-methyl-1H-pyrazol-4-yl)-5-(1-methylpyrrolidin-3-yloxy)phenyl)quinazolin-2-amine

Guidance literature:: Multi-step reaction with 6 steps

1.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0.33 h / 20 °C

1.2: 15 h

2.1: hydrogen / palladium 10% on activated carbon / methanol / 17 h / 20 °C / 760.05 Torr / Inert atmosphere of argon

3.1: isopropyl alcohol / 16 h / 100 °C

4.1: trifluoroacetic acid / dichloromethane / 0.25 h

4.2: pH ~ 11

5.1: acetic acid / methanol; water / 0.75 h / 20 °C

6.1: sodium triacetoxy borohydride / methanol; water / 0.5 h

With sodium triacetoxy borohydride; hydrogen; triphenylphosphine; trifluoroacetic acid; diethylazodicarboxylate; palladium 10% on activated carbon; acetic acid; In tetrahydrofuran; methanol; dichloromethane; water; isopropyl alcohol; 1.1: Mitsunobu reaction / 1.2: Mitsunobu reaction;