1-(1-(butylsulfonyl)piperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)urea

Base Information

Chemical Name:1-(1-(butylsulfonyl)piperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)urea
CAS No.:1448851-46-4
Molecular Formula:C₁₇H₂₄F₃N₃O₄S
Molecular Weight:423.456
Hs Code.:

Synonyms:1-(1-(butylsulfonyl)piperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)urea

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Chemical Property of 1-(1-(butylsulfonyl)piperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)urea

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Technology Process of 1-(1-(butylsulfonyl)piperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)urea

There total 3 articles about 1-(1-(butylsulfonyl)piperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1-(piperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)urea

: 2386-60-9
perfluoro-1-butanesulfonyl fluoride

: 1448851-46-4
1-(1-(butylsulfonyl)piperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)urea

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 12h; Inert atmosphere;
DOI:10.1021/jm500694p

Reference yield:

: 35037-73-1
1-isocyanato-4-trifluoromethoxy-benzene

: 1448851-46-4
1-(1-(butylsulfonyl)piperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)urea

Guidance literature:: Multi-step reaction with 3 steps

1: dichloromethane / 12 h / Reflux; Inert atmosphere

2: hydrogenchloride / methanol / 2 h / Reflux; Inert atmosphere

3: triethylamine / dichloromethane / 12 h / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; triethylamine; In methanol; dichloromethane;
DOI:10.1021/jm500694p

Reference yield:

: 87120-72-7
1-(tert-butoxycarbonyl)-4-aminopiperidine

: 1448851-46-4
1-(1-(butylsulfonyl)piperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)urea

Guidance literature:: Multi-step reaction with 3 steps

1: dichloromethane / 12 h / Reflux; Inert atmosphere

2: hydrogenchloride / methanol / 2 h / Reflux; Inert atmosphere

3: triethylamine / dichloromethane / 12 h / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; triethylamine; In methanol; dichloromethane;
DOI:10.1021/jm500694p