N-2,N⁶-Bis<(benzyloxy)carbonyl>-L-lysyl>-L-alanyl>-N'-<(tert-butyloxy)carbonyl>hexane-1,6-diamine

Base Information

• Chemical Name: N-2,N⁶-Bis<(benzyloxy)carbonyl>-L-lysyl>-L-alanyl>-N'-<(tert-butyloxy)carbonyl>hexane-1,6-diamine
• CAS No.: 145118-38-3
• Molecular Formula: C₃₆H₅₃N₅O₈
• Molecular Weight: 683.846

Synonyms:N-2,N⁶-Bis<(benzyloxy)carbonyl>-L-lysyl>-L-alanyl>-N'-<(tert-butyloxy)carbonyl>hexane-1,6-diamine

Chemical Property of N-2,N⁶-Bis<(benzyloxy)carbonyl>-L-lysyl>-L-alanyl>-N'-<(tert-butyloxy)carbonyl>hexane-1,6-diamine

Chemical Property:

Purity/Quality:

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Technology Process of N-2,N⁶-Bis<(benzyloxy)carbonyl>-L-lysyl>-L-alanyl>-N'-<(tert-butyloxy)carbonyl>hexane-1,6-diamine

There total 3 articles about N-2,N⁶-Bis<(benzyloxy)carbonyl>-L-lysyl>-L-alanyl>-N'-<(tert-butyloxy)carbonyl>hexane-1,6-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.8%

4-nitrophenyl N2,N6-bis[(phenylmethoxy)carbonyl]-L-lysinate (21160-82-7) + N-(L-Alanyl)-N'-<(tert-butyloxy)carbonyl>hexane-1,6-diamine (145118-13-4) → N-2,N6-Bis<(benzyloxy)carbonyl>-L-lysyl>-L-alanyl>-N'-<(tert-butyloxy)carbonyl>hexane-1,6-diamine (145118-38-3)

Guidance literature:

In tetrahydrofuran; for 18h;

DOI:10.1002/hlca.19920750617

Reference yield:

N-(tert-butoxycarbonyl)-1,6-diaminohexane hydrochloride (65915-94-8) → N-2,N6-Bis<(benzyloxy)carbonyl>-L-lysyl>-L-alanyl>-N'-<(tert-butyloxy)carbonyl>hexane-1,6-diamine (145118-38-3)

Guidance literature:

Multi-step reaction with 3 steps

1: Et₃N / tetrahydrofuran; H₂O / 18 h / Ambient temperature

2: 98.6 percent / H₂ / 10percent Pd/C / methanol / 20 h

3: 95.8 percent / tetrahydrofuran / 18 h

With hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; water;

DOI:10.1002/hlca.19920750617

Reference yield:

N--L-alanyl>-N'-<(tert-butyloxy)carbonyl>hexane-1,6-diamine (145118-12-3) → N-2,N6-Bis<(benzyloxy)carbonyl>-L-lysyl>-L-alanyl>-N'-<(tert-butyloxy)carbonyl>hexane-1,6-diamine (145118-38-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 98.6 percent / H₂ / 10percent Pd/C / methanol / 20 h

2: 95.8 percent / tetrahydrofuran / 18 h

With hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol;

DOI:10.1002/hlca.19920750617

upstream raw materials:

4-nitrophenyl N₂,N₆-bis[(phenylmethoxy)carbonyl]-L-lysinate

N-(L-Alanyl)-N'-<(tert-butyloxy)carbonyl>hexane-1,6-diamine

N-(tert-butoxycarbonyl)-1,6-diaminohexane hydrochloride

N--L-alanyl>-N'-<(tert-butyloxy)carbonyl>hexane-1,6-diamine

Downstream raw materials:

N-2,N⁶-Bis-<(benzyloxy)carbonyl>-L-lysyl>-L-alanyl>hexane-1,6-diamine Hydrochloride

N-2,N⁶-Bis<(benzyloxy)carbonyl>-L-lysyl>-L-alanyl>-N'-<(1H-indol-3-yl)acetyl>hexane-1,6-diamine

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