1,3-bis(4-methoxybenzyloxy)-6-(3-hydroxyprop-1-ynyl)-5-[2-(trifluoroacetamido)ethyl]benzene

Base Information

Chemical Name:1,3-bis(4-methoxybenzyloxy)-6-(3-hydroxyprop-1-ynyl)-5-[2-(trifluoroacetamido)ethyl]benzene
CAS No.:1314093-91-8
Molecular Formula:C₂₉H₂₈F₃NO₆
Molecular Weight:543.54
Hs Code.:

Synonyms:1,3-bis(4-methoxybenzyloxy)-6-(3-hydroxyprop-1-ynyl)-5-[2-(trifluoroacetamido)ethyl]benzene

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Chemical Property of 1,3-bis(4-methoxybenzyloxy)-6-(3-hydroxyprop-1-ynyl)-5-[2-(trifluoroacetamido)ethyl]benzene

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Technology Process of 1,3-bis(4-methoxybenzyloxy)-6-(3-hydroxyprop-1-ynyl)-5-[2-(trifluoroacetamido)ethyl]benzene

There total 6 articles about 1,3-bis(4-methoxybenzyloxy)-6-(3-hydroxyprop-1-ynyl)-5-[2-(trifluoroacetamido)ethyl]benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 1314093-89-4
C₂₆H₂₅F₃INO₅

: 107-19-7
propargyl alcohol

: 1314093-91-8
1,3-bis(4-methoxybenzyloxy)-6-(3-hydroxyprop-1-ynyl)-5-[2-(trifluoroacetamido)ethyl]benzene

Guidance literature:: C₂₆H₂₅F₃INO₅; With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; at 30 ℃; for 0.333333h;

propargyl alcohol; for 48h; Reflux;
DOI:10.1021/jo2009615

Reference yield:

: 1314093-97-4
3,5-bis(4-methoxybenzyloxy)benzaldehyde

: 1314093-91-8
1,3-bis(4-methoxybenzyloxy)-6-(3-hydroxyprop-1-ynyl)-5-[2-(trifluoroacetamido)ethyl]benzene

Guidance literature:: Multi-step reaction with 4 steps

1.1: ammonium acetate / 1.5 h / Reflux

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 65 °C

2.2: 1 h / 0 °C

3.1: N-iodo-succinimide / N,N-dimethyl-formamide / 18 h / 20 °C

4.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / 0.33 h / 30 °C

4.2: 48 h / Reflux

With bis-triphenylphosphine-palladium(II) chloride; N-iodo-succinimide; copper(l) iodide; lithium aluminium tetrahydride; ammonium acetate; In tetrahydrofuran; N,N-dimethyl-formamide; 4.1: Sonogashira coupling / 4.2: Sonogashira coupling;
DOI:10.1021/jo2009615

Reference yield:

: 1314093-99-6
1,3-bis(4-methoxybenzyloxy)-5-[(E)-2-nitroethenyl]benzene

: 1314093-91-8
1,3-bis(4-methoxybenzyloxy)-6-(3-hydroxyprop-1-ynyl)-5-[2-(trifluoroacetamido)ethyl]benzene

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 65 °C

1.2: 1 h / 0 °C

2.1: N-iodo-succinimide / N,N-dimethyl-formamide / 18 h / 20 °C

3.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / 0.33 h / 30 °C

3.2: 48 h / Reflux

With bis-triphenylphosphine-palladium(II) chloride; N-iodo-succinimide; copper(l) iodide; lithium aluminium tetrahydride; In tetrahydrofuran; N,N-dimethyl-formamide; 3.1: Sonogashira coupling / 3.2: Sonogashira coupling;
DOI:10.1021/jo2009615