N-<3-(2-tetrahydropyranyloxy)benzyl>-2-<3-(4-iodophenyl)propionamido>acetamide

Base Information

• Chemical Name: N-<3-(2-tetrahydropyranyloxy)benzyl>-2-<3-(4-iodophenyl)propionamido>acetamide
• CAS No.: 147949-90-4
• Molecular Formula: C₂₃H₂₇IN₂O₄
• Molecular Weight: 522.383
• Mol file: 147949-90-4.mol

Synonyms:N-<3-(2-tetrahydropyranyloxy)benzyl>-2-<3-(4-iodophenyl)propionamido>acetamide

Chemical Property of N-<3-(2-tetrahydropyranyloxy)benzyl>-2-<3-(4-iodophenyl)propionamido>acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-<3-(2-tetrahydropyranyloxy)benzyl>-2-<3-(4-iodophenyl)propionamido>acetamide

There total 3 articles about N-<3-(2-tetrahydropyranyloxy)benzyl>-2-<3-(4-iodophenyl)propionamido>acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

3,4-dihydro-2H-pyran (110-87-2) + N-(3-hydroxybenzyl)-2-<3-(4-iodophenyl)propionamido>acetamide (147949-77-7) → N-<3-(2-tetrahydropyranyloxy)benzyl>-2-<3-(4-iodophenyl)propionamido>acetamide (147949-90-4)

Guidance literature:

With toluene-4-sulfonic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; at 23 ℃; for 2h;

DOI:10.1021/jo00058a024

Reference yield:

3-hydroxybenzylamine (73604-31-6) → N-<3-(2-tetrahydropyranyloxy)benzyl>-2-<3-(4-iodophenyl)propionamido>acetamide (147949-90-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 1) Et₃N, ClCO₂Et / 1) THF, -10 deg C, 5 min, 2) THF, H₂O, 0 deg C, 15 min

2: 1) 2N HCl, 2) Et₃N, ClCO₂Et / 1) MeOH, 50 deg C, 30 min, 2) THF, H₂O, 0 deg C, 10 min

3: 75 percent / p-TosOH / tetrahydrofuran; CH₂Cl₂; dimethylformamide / 2 h / 23 °C

With hydrogenchloride; chloroformic acid ethyl ester; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jo00058a024

Reference yield:

2-<(tert-butyloxycarbonyl)amino>-N-(3-hydroxybenzyl)acetamide (147949-76-6) → N-<3-(2-tetrahydropyranyloxy)benzyl>-2-<3-(4-iodophenyl)propionamido>acetamide (147949-90-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) 2N HCl, 2) Et₃N, ClCO₂Et / 1) MeOH, 50 deg C, 30 min, 2) THF, H₂O, 0 deg C, 10 min

2: 75 percent / p-TosOH / tetrahydrofuran; CH₂Cl₂; dimethylformamide / 2 h / 23 °C

With hydrogenchloride; chloroformic acid ethyl ester; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jo00058a024

upstream raw materials:

3,4-dihydro-2H-pyran

N-(3-hydroxybenzyl)-2-<3-(4-iodophenyl)propionamido>acetamide

3-hydroxybenzylamine

2-<(tert-butyloxycarbonyl)amino>-N-(3-hydroxybenzyl)acetamide