N²-benzoyl-2',3'-bis-O-(tert-butyldimethylsilyl)guanosine 5'-O-(methyl N,N-diisopropylphosphoramidite)

Base Information

• Chemical Name: N²-benzoyl-2',3'-bis-O-(tert-butyldimethylsilyl)guanosine 5'-O-(methyl N,N-diisopropylphosphoramidite)
• CAS No.: 102302-24-9
• Molecular Formula: C₃₆H₆₁N₆O₇PSi₂
• Molecular Weight: 777.061

Synonyms:N²-benzoyl-2',3'-bis-O-(tert-butyldimethylsilyl)guanosine 5'-O-(methyl N,N-diisopropylphosphoramidite)

Chemical Property of N²-benzoyl-2',3'-bis-O-(tert-butyldimethylsilyl)guanosine 5'-O-(methyl N,N-diisopropylphosphoramidite)

Chemical Property:

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Technology Process of N²-benzoyl-2',3'-bis-O-(tert-butyldimethylsilyl)guanosine 5'-O-(methyl N,N-diisopropylphosphoramidite)

There total 1 articles about N²-benzoyl-2',3'-bis-O-(tert-butyldimethylsilyl)guanosine 5'-O-(methyl N,N-diisopropylphosphoramidite) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

N2-Benzoyl-2',3'-bis-O-(tert-butyldimethylsilyl)guanosin (72409-45-1) + N,N-diisopropylmethylphosphonamidic chloride (86030-43-5) → N2-benzoyl-2',3'-bis-O-(tert-butyldimethylsilyl)guanosine 5'-O-(methyl N,N-diisopropylphosphoramidite) (102302-24-9)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; for 1h; Ambient temperature;

DOI:10.1021/jo00251a010

Reference yield:

N2-benzoyl-2',3'-bis-O-(tert-butyldimethylsilyl)guanosine 5'-O-(methyl N,N-diisopropylphosphoramidite) (102302-24-9) + N6-Benzoyl-5'-O-(monomethoxytrityl)adenosine (69504-00-3) → C97H125N15O22P2Si4 (102302-27-2)

Guidance literature:

With 1H-tetrazole; 2,3,5-trimethyl-pyridine; water; iodine; Multistep reaction; 1.) THF, 1 h, 2.) THF;

DOI:10.1016/S0040-4039(00)94965-7

upstream raw materials:

N²-Benzoyl-2',3'-bis-O-(tert-butyldimethylsilyl)guanosin

N,N-diisopropylmethylphosphonamidic chloride

Downstream raw materials:

C₉₇H₁₂₅N₁₅O₂₂P₂Si₄

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