2-[(1S,3S)-4-(tert-Butyl-diphenyl-silanyloxy)-1,3-dimethyl-butyl]-6-methoxy-7-methyl-benzofuran-5-ol

Base Information

Chemical Name:2-[(1S,3S)-4-(tert-Butyl-diphenyl-silanyloxy)-1,3-dimethyl-butyl]-6-methoxy-7-methyl-benzofuran-5-ol
CAS No.:638188-68-8
Molecular Formula:C₃₂H₄₀O₄Si
Molecular Weight:516.753
Hs Code.:

Synonyms:2-[(1S,3S)-4-(tert-Butyl-diphenyl-silanyloxy)-1,3-dimethyl-butyl]-6-methoxy-7-methyl-benzofuran-5-ol

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Chemical Property of 2-[(1S,3S)-4-(tert-Butyl-diphenyl-silanyloxy)-1,3-dimethyl-butyl]-6-methoxy-7-methyl-benzofuran-5-ol

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Technology Process of 2-[(1S,3S)-4-(tert-Butyl-diphenyl-silanyloxy)-1,3-dimethyl-butyl]-6-methoxy-7-methyl-benzofuran-5-ol

There total 13 articles about 2-[(1S,3S)-4-(tert-Butyl-diphenyl-silanyloxy)-1,3-dimethyl-butyl]-6-methoxy-7-methyl-benzofuran-5-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (3S,5S)-6-(tert-Butyl-diphenyl-silanyloxy)-1-(4-methoxy-2,5-bis-methoxymethoxy-3-methyl-phenyl)-3,5-dimethyl-hexan-2-one

: 638188-68-8
2-[(1S,3S)-4-(tert-Butyl-diphenyl-silanyloxy)-1,3-dimethyl-butyl]-6-methoxy-7-methyl-benzofuran-5-ol

Guidance literature:: With trifluorormethanesulfonic acid; MS 4 Angstroem; In ethanol; toluene; at 80 ℃; for 0.166667h;
DOI:10.1021/ol035846x

Reference yield:

: 1760-80-1
2-methoxy-3-methylbenzene-1,4-diol

: 638188-68-8
2-[(1S,3S)-4-(tert-Butyl-diphenyl-silanyloxy)-1,3-dimethyl-butyl]-6-methoxy-7-methyl-benzofuran-5-ol

Guidance literature:: Multi-step reaction with 6 steps

1: NaH / dimethylformamide / 0.5 h / 0 °C

2: N-bromosuccinimide / CHCl₃ / 48 h / 5 °C

3: Mg / tetrahydrofuran / 2 h / Heating

4: 96 percent / CuI / 0.5 h / -30 °C

5: (COCl)2; DMSO; Et₃N / CH₂Cl₂ / -78 - 20 °C

6: TfOH; MS 4 Angstroem / ethanol; toluene / 0.17 h / 80 °C

With N-Bromosuccinimide; copper(l) iodide; oxalyl dichloride; trifluorormethanesulfonic acid; MS 4 Angstroem; sodium hydride; magnesium; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; chloroform; N,N-dimethyl-formamide; toluene; 5: Swern oxidation;
DOI:10.1021/ol035846x

Reference yield:

: 91751-24-5,92817-88-4,123284-89-9,112897-04-8
(R)-3-[(tert-butyldiphenylsilyl)oxy]-2-methylpropanal

: 638188-68-8
2-[(1S,3S)-4-(tert-Butyl-diphenyl-silanyloxy)-1,3-dimethyl-butyl]-6-methoxy-7-methyl-benzofuran-5-ol

Guidance literature:: Multi-step reaction with 8 steps

1.1: n-BuLi / H₂O; tetrahydrofuran

2.1: lithium tri-sec-butylborohydride / 2 h / -90 - -60 °C

2.2: hexamethylphosphoric triamide / 12 h / -78 °C

3.1: i-Bu₂AlH / 2 h / -78 °C

4.1: n-BuLi / 0 °C

5.1: m-chloroperbenzoic acid / CH₂Cl₂ / 20 °C

6.1: 96 percent / CuI / 0.5 h / -30 °C

7.1: (COCl)2; DMSO; Et₃N / CH₂Cl₂ / -78 - 20 °C

8.1: TfOH; MS 4 Angstroem / ethanol; toluene / 0.17 h / 80 °C

With copper(l) iodide; n-butyllithium; oxalyl dichloride; trifluorormethanesulfonic acid; MS 4 Angstroem; L-Selectride; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; ethanol; dichloromethane; water; toluene; 1.1: Horner-Wadsworth-Emmons olefination / 7.1: Swern oxidation;
DOI:10.1021/ol035846x