1-[2,6-dichloro-4-(1,2,2,3,3,3-hexafluoro-1-(trifluoromethyl)propyl)phenyl]-4-(4-fluoro-3-nitrophenyl)-1H-1,2,3-triazole

Base Information

Chemical Name:1-[2,6-dichloro-4-(1,2,2,3,3,3-hexafluoro-1-(trifluoromethyl)propyl)phenyl]-4-(4-fluoro-3-nitrophenyl)-1H-1,2,3-triazole
CAS No.:1334128-64-1
Molecular Formula:C₁₈H₆Cl₂F₁₀N₄O₂
Molecular Weight:571.161
Hs Code.:

Synonyms:1-[2,6-dichloro-4-(1,2,2,3,3,3-hexafluoro-1-(trifluoromethyl)propyl)phenyl]-4-(4-fluoro-3-nitrophenyl)-1H-1,2,3-triazole

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Chemical Property of 1-[2,6-dichloro-4-(1,2,2,3,3,3-hexafluoro-1-(trifluoromethyl)propyl)phenyl]-4-(4-fluoro-3-nitrophenyl)-1H-1,2,3-triazole

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Technology Process of 1-[2,6-dichloro-4-(1,2,2,3,3,3-hexafluoro-1-(trifluoromethyl)propyl)phenyl]-4-(4-fluoro-3-nitrophenyl)-1H-1,2,3-triazole

There total 4 articles about 1-[2,6-dichloro-4-(1,2,2,3,3,3-hexafluoro-1-(trifluoromethyl)propyl)phenyl]-4-(4-fluoro-3-nitrophenyl)-1H-1,2,3-triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1211528-74-3
4-ethynyl-1-fluoro-2-nitrobenzene

: 1334128-63-0
2-azido-1,3-dichloro-5-(1,2,2,3,3,3-hexafluoro-1-(trifluoromethyl)propyl)benzene

: 1334128-64-1
1-[2,6-dichloro-4-(1,2,2,3,3,3-hexafluoro-1-(trifluoromethyl)propyl)phenyl]-4-(4-fluoro-3-nitrophenyl)-1H-1,2,3-triazole

Guidance literature:: copper(ll) sulfate pentahydrate; sodium L-ascorbate; In water; tert-butyl alcohol; at 20 ℃; for 96h;

Reference yield:

: 364-73-8
4-Bromo-1-fluoro-2-nitrobenzene

: 1334128-64-1
1-[2,6-dichloro-4-(1,2,2,3,3,3-hexafluoro-1-(trifluoromethyl)propyl)phenyl]-4-(4-fluoro-3-nitrophenyl)-1H-1,2,3-triazole

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / triphenylphosphine; palladium diacetate / 4.25 h / 100 °C / Inert atmosphere; Reflux

2: sodium L-ascorbate; copper(ll) sulfate pentahydrate / water; tert-butyl alcohol / 96 h / 20 °C

With triethylamine; copper(ll) sulfate pentahydrate; palladium diacetate; sodium L-ascorbate; triphenylphosphine; In water; tert-butyl alcohol;

Reference yield:

: 1207315-63-6
4-(1,2,2,3,3,3-hexafluoro-1-trifluoromethylpropyl)phenylamine

: 1334128-64-1
1-[2,6-dichloro-4-(1,2,2,3,3,3-hexafluoro-1-(trifluoromethyl)propyl)phenyl]-4-(4-fluoro-3-nitrophenyl)-1H-1,2,3-triazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-chloro-succinimide / dichloromethane / 20 °C

2.1: hydrogenchloride / water / 0.5 h / 20 °C

2.2: 0.5 h / 0 - 5 °C

2.3: 0 - 20 °C

3.1: sodium L-ascorbate; copper(ll) sulfate pentahydrate / water; tert-butyl alcohol / 96 h / 20 °C

With hydrogenchloride; N-chloro-succinimide; copper(ll) sulfate pentahydrate; sodium L-ascorbate; In dichloromethane; water; tert-butyl alcohol;