3-[N'-benzyloxycarbonyl-N-(3-methylbutyl)hydrazino]-3-oxopropionic acid tert-butyl ester

Base Information

Chemical Name:3-[N'-benzyloxycarbonyl-N-(3-methylbutyl)hydrazino]-3-oxopropionic acid tert-butyl ester
CAS No.:926889-83-0
Molecular Formula:C₂₀H₃₀N₂O₅
Molecular Weight:378.469
Hs Code.:

Synonyms:3-[N'-benzyloxycarbonyl-N-(3-methylbutyl)hydrazino]-3-oxopropionic acid tert-butyl ester

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Chemical Property of 3-[N'-benzyloxycarbonyl-N-(3-methylbutyl)hydrazino]-3-oxopropionic acid tert-butyl ester

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Technology Process of 3-[N'-benzyloxycarbonyl-N-(3-methylbutyl)hydrazino]-3-oxopropionic acid tert-butyl ester

There total 3 articles about 3-[N'-benzyloxycarbonyl-N-(3-methylbutyl)hydrazino]-3-oxopropionic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 926889-49-8
N'-(3-methylbutyl)hydrazinecarboxylic acid benzyl ester

: 40052-13-9
mono-tert-butyl malonate

: 926889-83-0
3-[N'-benzyloxycarbonyl-N-(3-methylbutyl)hydrazino]-3-oxopropionic acid tert-butyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 23 ℃; for 1h;
DOI:10.1016/j.tet.2006.11.053

Reference yield:

: 5331-43-1
N-benzyloxycarbonyl-hydrazine

: 926889-83-0
3-[N'-benzyloxycarbonyl-N-(3-methylbutyl)hydrazino]-3-oxopropionic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: methanol / 0.5 h / 23 °C

1.2: 77 percent / glacial acetic acid; sodium cyanoborohydride / methanol / 0 - 23 °C

2.1: 74 percent / HATU; N,N-diisopropylethylamine / dimethylformamide / 1 h / 23 °C

With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2006.11.053

Reference yield:

: 590-86-3
isovaleraldehyde

: 926889-83-0
3-[N'-benzyloxycarbonyl-N-(3-methylbutyl)hydrazino]-3-oxopropionic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: methanol / 0.5 h / 23 °C

1.2: 77 percent / glacial acetic acid; sodium cyanoborohydride / methanol / 0 - 23 °C

2.1: 74 percent / HATU; N,N-diisopropylethylamine / dimethylformamide / 1 h / 23 °C

With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2006.11.053