Technology Process of methyl (S)-N-[(tert-butyloxy)carbonyl]-[3-N-(benzyloxy)carbonylaminophenyl]glycine
There total 5 articles about methyl (S)-N-[(tert-butyloxy)carbonyl]-[3-N-(benzyloxy)carbonylaminophenyl]glycine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 90 percent / Na2S2O4; K2CO3; 1,1'-dioctyl-4,4'-bipyridinium bromide / H2O; CH2Cl2 / 8 h / 35 °C
2: 96 percent / 2,6-lutidine / CH2Cl2 / 0 - 20 °C
3: 66 percent / OsO4; t-butyl hypochlorite; (DHQ)2-PHAL / aq. NaOH; propan-1-ol / -5 °C
4: 74 percent / NaOCl; TEMPO; KBr / acetone / 1 h / 0 °C
5: pyridine
With
2,6-dimethylpyridine; 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; osmium(VIII) oxide; sodium dithionite; (DHQ)2-PHAL; tert-butylhypochlorite; potassium carbonate; 1,1’-di-n-octyl-4,4’-bipyridinium dibromide; potassium bromide;
In
pyridine; propan-1-ol; sodium hydroxide; dichloromethane; water; acetone;
1: Reduction / 2: Substitution / 3: Addition / 4: Oxidation / 5: Esterification;
DOI:10.1021/jo982161f
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 96 percent / 2,6-lutidine / CH2Cl2 / 0 - 20 °C
2: 66 percent / OsO4; t-butyl hypochlorite; (DHQ)2-PHAL / aq. NaOH; propan-1-ol / -5 °C
3: 74 percent / NaOCl; TEMPO; KBr / acetone / 1 h / 0 °C
4: pyridine
With
2,6-dimethylpyridine; 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; osmium(VIII) oxide; (DHQ)2-PHAL; tert-butylhypochlorite; potassium bromide;
In
pyridine; propan-1-ol; sodium hydroxide; dichloromethane; acetone;
1: Substitution / 2: Addition / 3: Oxidation / 4: Esterification;
DOI:10.1021/jo982161f
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 66 percent / OsO4; t-butyl hypochlorite; (DHQ)2-PHAL / aq. NaOH; propan-1-ol / -5 °C
2: 74 percent / NaOCl; TEMPO; KBr / acetone / 1 h / 0 °C
3: pyridine
With
2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; osmium(VIII) oxide; (DHQ)2-PHAL; tert-butylhypochlorite; potassium bromide;
In
pyridine; propan-1-ol; sodium hydroxide; acetone;
1: Addition / 2: Oxidation / 3: Esterification;
DOI:10.1021/jo982161f
