4-Amino-3-chloro-5-fluoro-6-(4-chloro-2-fluoro-3-methoxy-phenyl)picolinonitrile

Base Information

Chemical Name:4-Amino-3-chloro-5-fluoro-6-(4-chloro-2-fluoro-3-methoxy-phenyl)picolinonitrile
CAS No.:1391025-81-2
Molecular Formula:C₁₃H₇Cl₂F₂N₃O
Molecular Weight:330.121
Hs Code.:

Synonyms:4-Amino-3-chloro-5-fluoro-6-(4-chloro-2-fluoro-3-methoxy-phenyl)picolinonitrile

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Chemical Property of 4-Amino-3-chloro-5-fluoro-6-(4-chloro-2-fluoro-3-methoxy-phenyl)picolinonitrile

Chemical Property:

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Technology Process of 4-Amino-3-chloro-5-fluoro-6-(4-chloro-2-fluoro-3-methoxy-phenyl)picolinonitrile

There total 5 articles about 4-Amino-3-chloro-5-fluoro-6-(4-chloro-2-fluoro-3-methoxy-phenyl)picolinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1,3-propanediyl 4-chloro-2-fluoro-3-methoxyphenylboronate

: 1391025-87-8
4-amino-3,6-dichloro-5-fluoropicolinonitrile

: 1391025-81-2
4-Amino-3-chloro-5-fluoro-6-(4-chloro-2-fluoro-3-methoxy-phenyl)picolinonitrile

Guidance literature:: With potassium fluoride; bis-triphenylphosphine-palladium(II) chloride; In water; acetonitrile; at 75 ℃; for 2h; Inert atmosphere;

Reference yield:

: 17824-83-8
3,4,5,6-tetrachloropicolinonitrile

: 1391025-81-2
4-Amino-3-chloro-5-fluoro-6-(4-chloro-2-fluoro-3-methoxy-phenyl)picolinonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate; cesium fluoride / dimethyl sulfoxide / 4 h / 65 - 70 °C / Inert atmosphere

2: ammonium hydroxide / ethyl acetate; water / 18 - 23 °C

3: dimethyl sulfoxide; tetrahydrofuran / 0.75 h / 65 °C

4: sulfuryl dichloride / dichloromethane / 40 h / 20 °C

5: potassium fluoride / bis-triphenylphosphine-palladium(II) chloride / acetonitrile; water / 2 h / 75 °C / Inert atmosphere

With potassium fluoride; ammonium hydroxide; sulfuryl dichloride; potassium carbonate; cesium fluoride; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide; ethyl acetate; acetonitrile;

Reference yield:

: 24488-15-1
3-chloro-4,5,6-trifluoropicolinonitrile

: 1391025-81-2
4-Amino-3-chloro-5-fluoro-6-(4-chloro-2-fluoro-3-methoxy-phenyl)picolinonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: ammonium hydroxide / ethyl acetate; water / 18 - 23 °C

2: dimethyl sulfoxide; tetrahydrofuran / 0.75 h / 65 °C

3: sulfuryl dichloride / dichloromethane / 40 h / 20 °C

4: potassium fluoride / bis-triphenylphosphine-palladium(II) chloride / acetonitrile; water / 2 h / 75 °C / Inert atmosphere

With potassium fluoride; ammonium hydroxide; sulfuryl dichloride; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide; ethyl acetate; acetonitrile;