(S)-2-(2-(3-(3-fluoropyrrolidin-1-yl)phenyl)imidazo[1,2-a]pyridin-7-yl)-5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazine

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Chemical Name:(S)-2-(2-(3-(3-fluoropyrrolidin-1-yl)phenyl)imidazo[1,2-a]pyridin-7-yl)-5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazine
CAS No.:1417343-27-1
Molecular Formula:C₂₄H₂₂FN₇
Molecular Weight:427.484
Hs Code.:

Synonyms:(S)-2-(2-(3-(3-fluoropyrrolidin-1-yl)phenyl)imidazo[1,2-a]pyridin-7-yl)-5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazine

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Chemical Property of (S)-2-(2-(3-(3-fluoropyrrolidin-1-yl)phenyl)imidazo[1,2-a]pyridin-7-yl)-5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazine

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Technology Process of (S)-2-(2-(3-(3-fluoropyrrolidin-1-yl)phenyl)imidazo[1,2-a]pyridin-7-yl)-5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazine

There total 5 articles about (S)-2-(2-(3-(3-fluoropyrrolidin-1-yl)phenyl)imidazo[1,2-a]pyridin-7-yl)-5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.2%

: 1417343-24-8
2-(2-(3-bromophenyl)imidazo[1,2-a]pyridin-7-yl)-5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazine

: 136725-53-6,169750-17-8,136725-55-8
(S)-3-fluoropyrrolidine hydrochloride

: 1417343-27-1
(S)-2-(2-(3-(3-fluoropyrrolidin-1-yl)phenyl)imidazo[1,2-a]pyridin-7-yl)-5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazine

Guidance literature:: With palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; In toluene; at 100 ℃; for 16h; Sealed tube;

Reference yield:

: 1417343-29-3
2-((tert-butoxycarbonyl)amino)isonicotinic acid hydrochloride

: 1417343-27-1
(S)-2-(2-(3-(3-fluoropyrrolidin-1-yl)phenyl)imidazo[1,2-a]pyridin-7-yl)-5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazine

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.5 h / 20 °C / Sealed tube

1.2: 17 h / 65 °C

2.1: N-ethyl-N,N-diisopropylamine / ethanol / 90 °C / Sealed tube

3.1: palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate / toluene / 16 h / 100 °C / Sealed tube

With palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; N-ethyl-N,N-diisopropylamine; HATU; sodium t-butanolate; In ethanol; N,N-dimethyl-formamide; toluene;

Reference yield:

: 639091-75-1,470463-38-8
methyl 2-[(tert-butoxycarbonyl)amino]isonicotinate

: 1417343-27-1
(S)-2-(2-(3-(3-fluoropyrrolidin-1-yl)phenyl)imidazo[1,2-a]pyridin-7-yl)-5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazine

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium hydroxide / methanol / 0.17 h / 50 °C

1.2: 20 °C

2.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.5 h / 20 °C / Sealed tube

2.2: 17 h / 65 °C

3.1: N-ethyl-N,N-diisopropylamine / ethanol / 90 °C / Sealed tube

4.1: palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate / toluene / 16 h / 100 °C / Sealed tube

With palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; N-ethyl-N,N-diisopropylamine; HATU; potassium hydroxide; sodium t-butanolate; In methanol; ethanol; N,N-dimethyl-formamide; toluene;