VUF 8430 dihydrobromide

Base Information

• Chemical Name: VUF 8430 dihydrobromide
• CAS No.: 100130-32-3
• Molecular Formula: C4H11 N5 S . 2 Br H
• Molecular Weight: 0
• European Community (EC) Number: 663-854-9
• DSSTox Substance ID: DTXSID60142970
• Wikipedia: VUF-8430
• ChEMBL ID: CHEMBL5087502
• Mol file: 100130-32-3.mol

Synonyms:VUF 8430 dihydrobromide;100130-32-3;98021-17-1;VUF 8430 (hydrobromide);VUF 8430 (dihydrobromide);Pseudourea, 2-(2-guanidinoethyl)-2-thio-, dihydrobromide;S,2-Guanidinoethylisothiuronium bromide hydrobromide;Carbamimidothioic acid, 2-((aminoiminomethyl)amino)ethyl ester, dihydrobromide;2-(2-Guanidinoethyl)-2-thiopseudourea dihydrobromide;2-(diaminomethylideneamino)ethyl carbamimidothioate;dihydrobromide;2-(DIAMINOMETHYLIDENEAMINO)ETHYLSULFANYLMETHANIMIDAMIDE DIHYDROBROMIDE;2-[(Aminoiminomethyl)amino]ethyl carbamimidothioic acid ester dihydrobromide;2-(Carbamimidoylsulfanyl)ethane-1-guanidine dihydrobromide;VUF8430 (hydrobromide);C4H11N5S.2BrH;CHEMBL5087502;DTXSID60142970;C4-H11-N5-S.2Br-H;AKOS016353306;HY-107555;LS-126151;CS-0028868;VUF 8430 dihydrobromide, >=97% (NMR)

Chemical Property of VUF 8430 dihydrobromide

Chemical Property:

• Vapor Pressure: 4.91E-05mmHg at 25°C
• Boiling Point: 348.8°C at 760 mmHg
• Flash Point: 164.8°C
• PSA: 137.07000
• LogP: 3.00330
• Storage Temp.: room temp
• Solubility.: deionized water: soluble24mg/mL
• Hydrogen Bond Donor Count: 6
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 322.92379
• Heavy Atom Count: 12
• Complexity: 139

Purity/Quality:

95% ^*data from raw suppliers

VUF 8430 dihydrobromide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(CSC(=N)N)N=C(N)N.Br.Br
• Description: VUF8430 is a histamine H4 receptor agonist (Ki = 31.6 nM). It is selective for histamine H4 over H1 and H3 receptors in radioligand binding assays (Kis = >1 and 1 μM, respectively) and is less active in isolated guinea pig atria, which endogenously expresses high levels of H2 receptors (pD2 = 3.8). VUF8430 inhibits forskolin-induced, cAMP-mediated increases in β-galactosidase activity (EC50 = 50.1 nM). In vivo, VUF8430 (30 mg/kg) enhances HCl-induced formation of gastric lesions in rats. It also reduces mechanical and thermal allodynia in a mouse model of peripheral neuropathy induced by spared nerve injury (SNI).
• Uses: VUF 8430 Dihydrobromide is an H4 receptor agonist.

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