tert-butyl 4'-<(2-n-butyl-8-(phenylmethyl)-1,3,8-triazaspiro<4.5>dec-1-en-3-yl)methyl>biphenyl-2-carboxylate

Base Information

• Chemical Name: tert-butyl 4'-<(2-n-butyl-8-(phenylmethyl)-1,3,8-triazaspiro<4.5>dec-1-en-3-yl)methyl>biphenyl-2-carboxylate
• CAS No.: 138402-17-2
• Molecular Formula: C₃₆H₄₃N₃O₃
• Molecular Weight: 565.756

Synonyms:tert-butyl 4'-<(2-n-butyl-8-(phenylmethyl)-1,3,8-triazaspiro<4.5>dec-1-en-3-yl)methyl>biphenyl-2-carboxylate

Chemical Property of tert-butyl 4'-<(2-n-butyl-8-(phenylmethyl)-1,3,8-triazaspiro<4.5>dec-1-en-3-yl)methyl>biphenyl-2-carboxylate

Chemical Property:

Purity/Quality:

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Useful:

Technology Process of tert-butyl 4'-<(2-n-butyl-8-(phenylmethyl)-1,3,8-triazaspiro<4.5>dec-1-en-3-yl)methyl>biphenyl-2-carboxylate

There total 3 articles about tert-butyl 4'-<(2-n-butyl-8-(phenylmethyl)-1,3,8-triazaspiro<4.5>dec-1-en-3-yl)methyl>biphenyl-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-amino-1-benzyl-4-ethoxycarbonylpiperidine (57611-55-9) → tert-butyl 4'-<(2-n-butyl-8-(phenylmethyl)-1,3,8-triazaspiro<4.5>dec-1-en-3-yl)methyl>biphenyl-2-carboxylate (138402-17-2)

Guidance literature:

Multi-step reaction with 2 steps

1: AcOH / xylene / 6.5 h / Heating

2: 1.) NaH / 1.) DMF, 15 min, 2.) DMF, 40 deg C, 3.5 h

With sodium hydride; acetic acid; In xylene;

DOI:10.1021/jm00074a018

Reference yield:

ethyl valerimidate (999-09-7) → tert-butyl 4'-<(2-n-butyl-8-(phenylmethyl)-1,3,8-triazaspiro<4.5>dec-1-en-3-yl)methyl>biphenyl-2-carboxylate (138402-17-2)

Guidance literature:

Multi-step reaction with 2 steps

1: AcOH / xylene / 6.5 h / Heating

2: 1.) NaH / 1.) DMF, 15 min, 2.) DMF, 40 deg C, 3.5 h

With sodium hydride; acetic acid; In xylene;

DOI:10.1021/jm00074a018

Reference yield:

4'-bromomethyl-biphenyl-2-carboxylic acid tert-butyl ester (114772-40-6) + 2-n-butyl-8-(phenylmethyl)-1,3,8-triazaspiro<4.5>dec-1-en-4-one (138402-16-1) → tert-butyl 4'-<(2-n-butyl-8-(phenylmethyl)-1,3,8-triazaspiro<4.5>dec-1-en-3-yl)methyl>biphenyl-2-carboxylate (138402-17-2)

Guidance literature:

With sodium hydride; Multistep reaction; 1.) DMF, 15 min, 2.) DMF, 40 deg C, 3.5 h;

DOI:10.1021/jm00074a018

upstream raw materials:

4'-bromomethyl-biphenyl-2-carboxylic acid tert-butyl ester

2-n-butyl-8-(phenylmethyl)-1,3,8-triazaspiro<4.5>dec-1-en-4-one

4-amino-1-benzyl-4-ethoxycarbonylpiperidine

ethyl valerimidate

Downstream raw materials:

tert-butyl 4'-<<2-n-butyl-4-oxo-8<(tert-butoxycarbonyl)methyl>-1,3,8-triazaspiro<4.5>dec-1-en-3-yl>methyl>biphenyl-2-carboxylate

tert-butyl 4'-<<2-n-butyl-4-oxo-8-(trifluoroacetyl)-1,3,8-triazaspiro<4.5>dec-1-en-3-yl>methyl>biphenyl-2-carboxylate

tert-butyl 4'-<(8-acetyl-2-n-butyl-4-oxo-1,3,8-triazaspiro<4.5>dec-1-en-3-yl)methyl>biphenyl-2-carboxylate

tert-butyl 4'-<(2-n-butyl-4-oxo-1,3,8-triazaspiro<4.5>dec-1-en-3-yl)methyl>biphenyl-2-carboxylate

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