2-(benzyloxy)-5-(2,4-dichloro-1-(methoxymethyl)-1H-indol-3-yl)pentanenitrile

Base Information

• Chemical Name: 2-(benzyloxy)-5-(2,4-dichloro-1-(methoxymethyl)-1H-indol-3-yl)pentanenitrile
• CAS No.: 1254982-42-7
• Molecular Formula: C₂₂H₂₂Cl₂N₂O₂
• Molecular Weight: 417.335
• Mol file: 1254982-42-7.mol

Synonyms:2-(benzyloxy)-5-(2,4-dichloro-1-(methoxymethyl)-1H-indol-3-yl)pentanenitrile

Chemical Property of 2-(benzyloxy)-5-(2,4-dichloro-1-(methoxymethyl)-1H-indol-3-yl)pentanenitrile

Chemical Property:

Purity/Quality:

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Technology Process of 2-(benzyloxy)-5-(2,4-dichloro-1-(methoxymethyl)-1H-indol-3-yl)pentanenitrile

There total 1 articles about 2-(benzyloxy)-5-(2,4-dichloro-1-(methoxymethyl)-1H-indol-3-yl)pentanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C20H18Cl2N2O + chloromethyl methyl ether (107-30-2) → 2-(benzyloxy)-5-(2,4-dichloro-1-(methoxymethyl)-1H-indol-3-yl)pentanenitrile (1254982-42-7)

Guidance literature:

C₂₀H₁₈Cl₂N₂O; With sodium hydride; In tetrahydrofuran;

chloromethyl methyl ether; In tetrahydrofuran;

DOI:10.1021/ol102246d

Reference yield: 50.0%

2-(benzyloxy)-5-(2,4-dichloro-1-(methoxymethyl)-1H-indol-3-yl)pentanenitrile (1254982-42-7) + hydrocinnamic acid chloride (645-45-4) → N-((1S,2R,3R)-3-(benzyloxy)-6'-chloro-1'methoxymethyl-2'-oxospiro[cyclohexane-1,3'-indolin]-2-yl)-3-phenylpropanamide

Guidance literature:

2-(benzyloxy)-5-(2,4-dichloro-1-(methoxymethyl)-1H-indol-3-yl)pentanenitrile; With Schwartz's reagent; In dichloromethane; at 20 ℃; for 0.25h; Inert atmosphere;

hydrocinnamic acid chloride; In dichloromethane; at 20 ℃; stereoselective reaction; Inert atmosphere;

DOI:10.1021/ol102246d

upstream raw materials:

chloromethyl methyl ether