N-(4-fluorobenzyl)-3-hydroxy-10-((2-hydroxyethyl)amino)-4-oxo-4,6,7,8,9,10-hexahydro-7,11-ethanopyrimido[1,2-a]azepine-2-carboxamide trifluoroacetate

Base Information

Chemical Name:N-(4-fluorobenzyl)-3-hydroxy-10-((2-hydroxyethyl)amino)-4-oxo-4,6,7,8,9,10-hexahydro-7,11-ethanopyrimido[1,2-a]azepine-2-carboxamide trifluoroacetate
CAS No.:1241048-07-6
Molecular Formula:C₂HF₃O₂*C₂₁H₂₅FN₄O₄
Molecular Weight:530.476
Hs Code.:

N-(4-fluorobenzyl)-3-hydroxy-10-((2-hydroxyethyl)amino)-4-oxo-4,6,7,8,9,10-hexahydro-7,11-ethanopyrimido[1,2-a]azepine-2-carboxamide trifluoroacetate

Synonyms:N-(4-fluorobenzyl)-3-hydroxy-10-((2-hydroxyethyl)amino)-4-oxo-4,6,7,8,9,10-hexahydro-7,11-ethanopyrimido[1,2-a]azepine-2-carboxamide trifluoroacetate

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Chemical Property of N-(4-fluorobenzyl)-3-hydroxy-10-((2-hydroxyethyl)amino)-4-oxo-4,6,7,8,9,10-hexahydro-7,11-ethanopyrimido[1,2-a]azepine-2-carboxamide trifluoroacetate

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Technology Process of N-(4-fluorobenzyl)-3-hydroxy-10-((2-hydroxyethyl)amino)-4-oxo-4,6,7,8,9,10-hexahydro-7,11-ethanopyrimido[1,2-a]azepine-2-carboxamide trifluoroacetate

There total 1 articles about N-(4-fluorobenzyl)-3-hydroxy-10-((2-hydroxyethyl)amino)-4-oxo-4,6,7,8,9,10-hexahydro-7,11-ethanopyrimido[1,2-a]azepine-2-carboxamide trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1188424-55-6
10-amino-N-(4-fluorobenzyl)-3-hydroxy-4-oxo-4,6,7,8,9,10-hexahydro-7,10-ethanopyrimido[1,2-a]azepine-2-carboxamide

: 141-46-8
Glycolaldehyde

: 76-05-1
trifluoroacetic acid

: 1241048-07-6
N-(4-fluorobenzyl)-3-hydroxy-10-((2-hydroxyethyl)amino)-4-oxo-4,6,7,8,9,10-hexahydro-7,11-ethanopyrimido[1,2-a]azepine-2-carboxamide trifluoroacetate

Guidance literature:: 10-amino-N-(4-fluorobenzyl)-3-hydroxy-4-oxo-4,6,7,8,9,10-hexahydro-7,10-ethanopyrimido[1,2-a]azepine-2-carboxamide; With triethylamine; In methanol; at 20 ℃; for 0.5h;

Glycolaldehyde; With sodium cyanoborohydride; acetic acid; In methanol; at 20 ℃; for 2.5h;

trifluoroacetic acid; In methanol; water;

Reference yield: 52.0%

: 5781-53-3
monomethyl oxalyl chloride

: 1241048-07-6
N-(4-fluorobenzyl)-3-hydroxy-10-((2-hydroxyethyl)amino)-4-oxo-4,6,7,8,9,10-hexahydro-7,11-ethanopyrimido[1,2-a]azepine-2-carboxamide trifluoroacetate

: 124-40-3
dimethyl amine

: 1188426-12-1
N-(2-((4-Fluorobenzyl)carbamoyl)-3-hydroxy-4-oxo-6,7,8,9-tetrahydro-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl)-N-(2-hydroxyethyl)-N',N'-dimethylethanediamide

Guidance literature:: monomethyl oxalyl chloride; N-(4-fluorobenzyl)-3-hydroxy-10-((2-hydroxyethyl)amino)-4-oxo-4,6,7,8,9,10-hexahydro-7,11-ethanopyrimido[1,2-a]azepine-2-carboxamide trifluoroacetate; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 5h;

dimethyl amine; In methanol; at 85 ℃; for 18h;