1-(4-tert-butylbenzyl)-4-{3-[1-(4-chlorophenyl)-5-(4-methylphenyl)-1H-pyrazol-3-yl]propanoyl}piperazine

Base Information

Chemical Name:1-(4-tert-butylbenzyl)-4-{3-[1-(4-chlorophenyl)-5-(4-methylphenyl)-1H-pyrazol-3-yl]propanoyl}piperazine
CAS No.:1339035-79-8
Molecular Formula:C₃₄H₃₉ClN₄O
Molecular Weight:555.163
Hs Code.:

Synonyms:1-(4-tert-butylbenzyl)-4-{3-[1-(4-chlorophenyl)-5-(4-methylphenyl)-1H-pyrazol-3-yl]propanoyl}piperazine

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Chemical Property of 1-(4-tert-butylbenzyl)-4-{3-[1-(4-chlorophenyl)-5-(4-methylphenyl)-1H-pyrazol-3-yl]propanoyl}piperazine

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Technology Process of 1-(4-tert-butylbenzyl)-4-{3-[1-(4-chlorophenyl)-5-(4-methylphenyl)-1H-pyrazol-3-yl]propanoyl}piperazine

There total 3 articles about 1-(4-tert-butylbenzyl)-4-{3-[1-(4-chlorophenyl)-5-(4-methylphenyl)-1H-pyrazol-3-yl]propanoyl}piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 956-61-6
1-(4-tert-butylbenzyl)piperazine

: 1339036-14-4
3-[1-(4-chlorophenyl)-5-(4-methylphenyl)-1H-pyrazol-3-yl]propanoic acid

: 1339035-79-8
1-(4-tert-butylbenzyl)-4-{3-[1-(4-chlorophenyl)-5-(4-methylphenyl)-1H-pyrazol-3-yl]propanoyl}piperazine

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃;
DOI:10.1016/j.ejmech.2011.08.009

Reference yield:

: 122-00-9
para-methylacetophenone

: 1339035-79-8
1-(4-tert-butylbenzyl)-4-{3-[1-(4-chlorophenyl)-5-(4-methylphenyl)-1H-pyrazol-3-yl]propanoyl}piperazine

Guidance literature:: Multi-step reaction with 3 steps

1: Alkaline conditions

2: triethylamine / methanol / 4 h / Reflux

3: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In methanol; dichloromethane;
DOI:10.1016/j.ejmech.2011.08.009

Reference yield:

: 114150-50-4
4,6-dioxo-6-(4-methylphenyl)hexanoic acid

: 1339035-79-8
1-(4-tert-butylbenzyl)-4-{3-[1-(4-chlorophenyl)-5-(4-methylphenyl)-1H-pyrazol-3-yl]propanoyl}piperazine

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / methanol / 4 h / Reflux

2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In methanol; dichloromethane;
DOI:10.1016/j.ejmech.2011.08.009