(2R,3R)-1-{(1R,2R,6R)-2-[(2R)-2-(tert-butyl(diphenyl)silanyloxy)pent-4-enyl]-6-isopropyl-3-methylcyclohex-3-enyl}-3-methoxymethoxypent-4-en-2-ol

Base Information

Chemical Name:(2R,3R)-1-{(1R,2R,6R)-2-[(2R)-2-(tert-butyl(diphenyl)silanyloxy)pent-4-enyl]-6-isopropyl-3-methylcyclohex-3-enyl}-3-methoxymethoxypent-4-en-2-ol
CAS No.:503071-64-5
Molecular Formula:C₃₈H₅₆O₄Si
Molecular Weight:604.946
Hs Code.:

Synonyms:(2R,3R)-1-{(1R,2R,6R)-2-[(2R)-2-(tert-butyl(diphenyl)silanyloxy)pent-4-enyl]-6-isopropyl-3-methylcyclohex-3-enyl}-3-methoxymethoxypent-4-en-2-ol

Suppliers and Price of (2R,3R)-1-{(1R,2R,6R)-2-[(2R)-2-(tert-butyl(diphenyl)silanyloxy)pent-4-enyl]-6-isopropyl-3-methylcyclohex-3-enyl}-3-methoxymethoxypent-4-en-2-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2R,3R)-1-{(1R,2R,6R)-2-[(2R)-2-(tert-butyl(diphenyl)silanyloxy)pent-4-enyl]-6-isopropyl-3-methylcyclohex-3-enyl}-3-methoxymethoxypent-4-en-2-ol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2R,3R)-1-{(1R,2R,6R)-2-[(2R)-2-(tert-butyl(diphenyl)silanyloxy)pent-4-enyl]-6-isopropyl-3-methylcyclohex-3-enyl}-3-methoxymethoxypent-4-en-2-ol

There total 10 articles about (2R,3R)-1-{(1R,2R,6R)-2-[(2R)-2-(tert-butyl(diphenyl)silanyloxy)pent-4-enyl]-6-isopropyl-3-methylcyclohex-3-enyl}-3-methoxymethoxypent-4-en-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 62322-45-6
allyl methoxymethyl ether

: 402827-64-9
{(1R,2R,6R)-2-[(2R)-2-(tert-butyl(diphenyl)silanyloxy)pent-4-enyl]-6-isopropyl-3-methylcyclohex-3-enyl}acetaldehyde

: 503071-64-5
(2R,3R)-1-{(1R,2R,6R)-2-[(2R)-2-(tert-butyl(diphenyl)silanyloxy)pent-4-enyl]-6-isopropyl-3-methylcyclohex-3-enyl}-3-methoxymethoxypent-4-en-2-ol

Guidance literature:: allyl methoxymethyl ether; With sec.-butyllithium; (-)-B-methoxy-diisopinocamphenylborane; In tetrahydrofuran; cyclohexane; at -78 ℃; for 1h;

{(1R,2R,6R)-2-[(2R)-2-(tert-butyl(diphenyl)silanyloxy)pent-4-enyl]-6-isopropyl-3-methylcyclohex-3-enyl}acetaldehyde; With boron trifluoride diethyl etherate; In tetrahydrofuran; cyclohexane; at -78 ℃; for 14h;

With sodium hydroxide; dihydrogen peroxide; In tetrahydrofuran; cyclohexane; water; at 20 ℃; for 5h;
DOI:10.1016/j.tet.2003.08.057

Reference yield: 70.0%

: 62322-45-6
allyl methoxymethyl ether

: 402827-64-9
{(1R,2R,6R)-2-[(2R)-2-(tert-butyl(diphenyl)silanyloxy)pent-4-enyl]-6-isopropyl-3-methylcyclohex-3-enyl}acetaldehyde

: 503071-63-4
(2S,3S)-1-{(1R,2R,6R)-2-[(2R)-2-(tert-butyl(diphenyl)silanyloxy)pent-4-enyl]-6-isopropyl-3-methylcyclohex-3-enyl}-3-methoxymethoxypent-4-en-2-ol

: 503071-64-5
(2R,3R)-1-{(1R,2R,6R)-2-[(2R)-2-(tert-butyl(diphenyl)silanyloxy)pent-4-enyl]-6-isopropyl-3-methylcyclohex-3-enyl}-3-methoxymethoxypent-4-en-2-ol

Guidance literature:: allyl methoxymethyl ether; With sec.-butyllithium; (-)-B-methoxy-diisopinocamphenylborane; In tetrahydrofuran; cyclohexane; at -78 ℃; for 1h;

{(1R,2R,6R)-2-[(2R)-2-(tert-butyl(diphenyl)silanyloxy)pent-4-enyl]-6-isopropyl-3-methylcyclohex-3-enyl}acetaldehyde; With boron trifluoride diethyl etherate; In tetrahydrofuran; cyclohexane; at -78 ℃; for 5h;

With sodium hydroxide; dihydrogen peroxide; In tetrahydrofuran; cyclohexane; at 20 ℃;
DOI:10.1016/j.tet.2003.08.057

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 503071-64-5
(2R,3R)-1-{(1R,2R,6R)-2-[(2R)-2-(tert-butyl(diphenyl)silanyloxy)pent-4-enyl]-6-isopropyl-3-methylcyclohex-3-enyl}-3-methoxymethoxypent-4-en-2-ol

Guidance literature:: Multi-step reaction with 7 steps

1.1: 100 percent / imidazole / CH₂Cl₂ / 0 - 20 °C

2.1: 99 percent / AcOH / H₂O; tetrahydrofuran / 21 h / 20 °C

3.1: 98 percent / NaBH₄ / ethanol / 0.25 h / 20 °C

4.1: 100 percent / Et₃N / CH₂Cl₂ / 2 h / 0 - 20 °C

5.1: 95 percent / 18-crown-6 / acetonitrile / 6 h / 80 °C

6.1: DIBAL-H / toluene; hexane / 0.75 h / -78 °C

6.2: 100 percent / tartaric acid / H₂O; ethyl acetate; various solvents / 1 h / 20 °C

7.1: sec-BuLi; ¹Ipc₂BOMe / tetrahydrofuran; cyclohexane / 1 h / -78 °C

7.2: BF₃*Et₂O / tetrahydrofuran; cyclohexane / 5 h / -78 °C

7.3: 7 percent / NaOH; H₂O₂ / tetrahydrofuran; cyclohexane / 20 °C

With 1H-imidazole; sodium tetrahydroborate; 18-crown-6 ether; sec.-butyllithium; diisobutylaluminium hydride; acetic acid; triethylamine; (-)-B-methoxy-diisopinocamphenylborane; In tetrahydrofuran; ethanol; hexane; dichloromethane; cyclohexane; water; toluene; acetonitrile; 7.2: Brown allylation;
DOI:10.1016/j.tet.2003.08.057