Technology Process of (3R,4R,5R)-3-(benzoyloxy)-4-[3-(2,2-dimethylpropionyl)oxy-2,2-ethanopropyl]oxy-5,6-epoxyhex-1-ene
There total 7 articles about (3R,4R,5R)-3-(benzoyloxy)-4-[3-(2,2-dimethylpropionyl)oxy-2,2-ethanopropyl]oxy-5,6-epoxyhex-1-ene which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
tetrabutyl ammonium fluoride;
In
tetrahydrofuran;
for 1.5h;
Reflux;
DOI:10.1039/c1ob05142c
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: pyridine / 1 h / 0 °C
2.1: 2,6-dimethylpyridine / dichloromethane / 0 - 20 °C
3.1: N-Bromosuccinimide; barium carbonate; dibenzoyl peroxide / cyclohexane / 1 h / Reflux
3.2: 1 h / 110 °C
4.1: trimethylamine hydrochloride; triethylamine / acetonitrile / 1 h / 20 °C
5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.5 h / Reflux
With
pyridine; 2,6-dimethylpyridine; N-Bromosuccinimide; tetrabutyl ammonium fluoride; trimethylamine hydrochloride; triethylamine; barium carbonate; dibenzoyl peroxide;
In
tetrahydrofuran; dichloromethane; cyclohexane; acetonitrile;
DOI:10.1039/c1ob05142c
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 8 h / 130 °C
2.1: pyridine / 1 h / 0 °C
3.1: 2,6-dimethylpyridine / dichloromethane / 0 - 20 °C
4.1: N-Bromosuccinimide; barium carbonate; dibenzoyl peroxide / cyclohexane / 1 h / Reflux
4.2: 1 h / 110 °C
5.1: trimethylamine hydrochloride; triethylamine / acetonitrile / 1 h / 20 °C
6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.5 h / Reflux
With
pyridine; 2,6-dimethylpyridine; N-Bromosuccinimide; potassium tert-butylate; tetrabutyl ammonium fluoride; trimethylamine hydrochloride; triethylamine; barium carbonate; dibenzoyl peroxide;
In
tetrahydrofuran; 1-methyl-pyrrolidin-2-one; dichloromethane; cyclohexane; acetonitrile;
DOI:10.1039/c1ob05142c
