4-[8-(4-chloro-3-cyclopropylbenzyl)-1-oxa-2,8-diazaspiro[4.5]dec-2-en-3-yl]benzoic acid trifluoroacetate

Base Information

Chemical Name:4-[8-(4-chloro-3-cyclopropylbenzyl)-1-oxa-2,8-diazaspiro[4.5]dec-2-en-3-yl]benzoic acid trifluoroacetate
CAS No.:1350759-29-3
Molecular Formula:C₂HF₃O₂*C₂₄H₂₅ClN₂O₃
Molecular Weight:538.951
Hs Code.:

Synonyms:4-[8-(4-chloro-3-cyclopropylbenzyl)-1-oxa-2,8-diazaspiro[4.5]dec-2-en-3-yl]benzoic acid trifluoroacetate

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Chemical Property of 4-[8-(4-chloro-3-cyclopropylbenzyl)-1-oxa-2,8-diazaspiro[4.5]dec-2-en-3-yl]benzoic acid trifluoroacetate

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Technology Process of 4-[8-(4-chloro-3-cyclopropylbenzyl)-1-oxa-2,8-diazaspiro[4.5]dec-2-en-3-yl]benzoic acid trifluoroacetate

There total 3 articles about 4-[8-(4-chloro-3-cyclopropylbenzyl)-1-oxa-2,8-diazaspiro[4.5]dec-2-en-3-yl]benzoic acid trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₅H₂₇ClN₂O₃

: 76-05-1
trifluoroacetic acid

: 1350759-29-3
4-[8-(4-chloro-3-cyclopropylbenzyl)-1-oxa-2,8-diazaspiro[4.5]dec-2-en-3-yl]benzoic acid trifluoroacetate

Guidance literature:: C₂₅H₂₇ClN₂O₃; With water; lithium hydroxide; In tetrahydrofuran; at 70 ℃; for 3h;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: 86265-88-5
3-bromo-4-chloro-benzaldehyde

: 1350759-29-3
4-[8-(4-chloro-3-cyclopropylbenzyl)-1-oxa-2,8-diazaspiro[4.5]dec-2-en-3-yl]benzoic acid trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid / N,N-dimethyl-formamide

2: potassium carbonate / palladium diacetate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / toluene; water / 100 °C

3: water; lithium hydroxide / tetrahydrofuran / 3 h / 70 °C

With water; potassium carbonate; acetic acid; lithium hydroxide; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; In tetrahydrofuran; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1350761-82-8
methyl 4-[8-(3-bromo-4-chlorobenzyl)-1-oxa-2,8-diazaspiro[4.5]dec-2-en-3-yl]benzoate

: 1350759-29-3
4-[8-(4-chloro-3-cyclopropylbenzyl)-1-oxa-2,8-diazaspiro[4.5]dec-2-en-3-yl]benzoic acid trifluoroacetate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / palladium diacetate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / toluene; water / 100 °C

2: water; lithium hydroxide / tetrahydrofuran / 3 h / 70 °C

With water; potassium carbonate; lithium hydroxide; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; In tetrahydrofuran; water; toluene;