(R)-N-{(S)-1-[4-amino-4-(4-fluoro-benzyl)-piperidine-1-carbonyl]-2,2-dimethyl-propyl}-2-cyclopentylmethyl-3-(formyl-hydroxy-amino)-propionamide

Base Information

Chemical Name:(R)-N-{(S)-1-[4-amino-4-(4-fluoro-benzyl)-piperidine-1-carbonyl]-2,2-dimethyl-propyl}-2-cyclopentylmethyl-3-(formyl-hydroxy-amino)-propionamide
CAS No.:1091682-14-2
Molecular Formula:C₂₈H₄₃FN₄O₄
Molecular Weight:518.672
Hs Code.:

Synonyms:(R)-N-{(S)-1-[4-amino-4-(4-fluoro-benzyl)-piperidine-1-carbonyl]-2,2-dimethyl-propyl}-2-cyclopentylmethyl-3-(formyl-hydroxy-amino)-propionamide

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Chemical Property of (R)-N-{(S)-1-[4-amino-4-(4-fluoro-benzyl)-piperidine-1-carbonyl]-2,2-dimethyl-propyl}-2-cyclopentylmethyl-3-(formyl-hydroxy-amino)-propionamide

Chemical Property:

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Technology Process of (R)-N-{(S)-1-[4-amino-4-(4-fluoro-benzyl)-piperidine-1-carbonyl]-2,2-dimethyl-propyl}-2-cyclopentylmethyl-3-(formyl-hydroxy-amino)-propionamide

There total 12 articles about (R)-N-{(S)-1-[4-amino-4-(4-fluoro-benzyl)-piperidine-1-carbonyl]-2,2-dimethyl-propyl}-2-cyclopentylmethyl-3-(formyl-hydroxy-amino)-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 1091682-16-4
{1-{(S)-2-[(R)-3-(benzyloxyl-formyl-amino)-2-cyclopentylmethyl-propionylamino]-3,3-dimethy-butyryl}-4-(4-fluoro-benzyl)-piperidin-4-yl}-carbamic acid benzyl ester

: 1091682-14-2
(R)-N-{(S)-1-[4-amino-4-(4-fluoro-benzyl)-piperidine-1-carbonyl]-2,2-dimethyl-propyl}-2-cyclopentylmethyl-3-(formyl-hydroxy-amino)-propionamide

Guidance literature:: With hydrogen; palladium on activated carbon; In ethanol; for 2h;

Reference yield:

: 1091681-78-5
4-benzyloxycarbonylamino-4-(4-fluoro-benzyl)-piperidine-1-carboxylic acid tert-butyl ester

: 1091682-14-2
(R)-N-{(S)-1-[4-amino-4-(4-fluoro-benzyl)-piperidine-1-carbonyl]-2,2-dimethyl-propyl}-2-cyclopentylmethyl-3-(formyl-hydroxy-amino)-propionamide

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogenchloride / ethyl acetate

2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 18 h / 20 °C

3: hydrogenchloride / ethyl acetate

4: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 18 h / 20 °C

5: hydrogen / palladium on activated carbon / ethanol / 2 h

With hydrogenchloride; dmap; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated carbon; In ethanol; dichloromethane; ethyl acetate;

Reference yield:

: 917834-41-4
tert-butyl 4-(benzyloxycarbonylamino)-4-(hydroxymethyl)piperidine-1-carboxylate

: 1091682-14-2
(R)-N-{(S)-1-[4-amino-4-(4-fluoro-benzyl)-piperidine-1-carbonyl]-2,2-dimethyl-propyl}-2-cyclopentylmethyl-3-(formyl-hydroxy-amino)-propionamide

Guidance literature:: Multi-step reaction with 7 steps

1: tetrachloromethane; triphenylphosphine / benzene / 4 h / Heating / reflux

2: palladium diacetate; triphenylphosphine / tetrahydrofuran / 20 h / 0 - 20 °C

3: hydrogenchloride / ethyl acetate

4: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 18 h / 20 °C

5: hydrogenchloride / ethyl acetate

6: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 18 h / 20 °C

7: hydrogen / palladium on activated carbon / ethanol / 2 h

With hydrogenchloride; tetrachloromethane; dmap; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; palladium diacetate; palladium on activated carbon; triphenylphosphine; In tetrahydrofuran; ethanol; dichloromethane; ethyl acetate; benzene;