N-{3-[3-(dimethylamino)propyl]-5-(trifluoromethyl)phenyl}-4-(3-methyl-1H-indazol-6-yl)phthalazin-1-amine trifluoroacetate

Base Information

Chemical Name:N-{3-[3-(dimethylamino)propyl]-5-(trifluoromethyl)phenyl}-4-(3-methyl-1H-indazol-6-yl)phthalazin-1-amine trifluoroacetate
CAS No.:1365803-29-7
Molecular Formula:C₂HF₃O₂*C₂₈H₂₇F₃N₆
Molecular Weight:618.582
Hs Code.:

Synonyms:N-{3-[3-(dimethylamino)propyl]-5-(trifluoromethyl)phenyl}-4-(3-methyl-1H-indazol-6-yl)phthalazin-1-amine trifluoroacetate

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Chemical Property of N-{3-[3-(dimethylamino)propyl]-5-(trifluoromethyl)phenyl}-4-(3-methyl-1H-indazol-6-yl)phthalazin-1-amine trifluoroacetate

Chemical Property:

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Technology Process of N-{3-[3-(dimethylamino)propyl]-5-(trifluoromethyl)phenyl}-4-(3-methyl-1H-indazol-6-yl)phthalazin-1-amine trifluoroacetate

There total 8 articles about N-{3-[3-(dimethylamino)propyl]-5-(trifluoromethyl)phenyl}-4-(3-methyl-1H-indazol-6-yl)phthalazin-1-amine trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1365803-31-1
tert-butyl 6-[4-({3-[3-(dimethylamino)propyl]-5-(trifluoromethyl)phenyl}amino)phthalazin-1-yl]-3-methyl-1H-indazole-1-carboxylate

: 76-05-1
trifluoroacetic acid

: 1365803-29-7
N-{3-[3-(dimethylamino)propyl]-5-(trifluoromethyl)phenyl}-4-(3-methyl-1H-indazol-6-yl)phthalazin-1-amine trifluoroacetate

Guidance literature:: In dichloromethane; at 100 ℃; for 0.5h; microwave irradiation;

Reference yield:

: 112704-79-7
2-fluoro-4-bromobenzoic acid

: 1365803-29-7
N-{3-[3-(dimethylamino)propyl]-5-(trifluoromethyl)phenyl}-4-(3-methyl-1H-indazol-6-yl)phthalazin-1-amine trifluoroacetate

Guidance literature:: Multi-step reaction with 9 steps

1: dmap; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

2: diethyl ether; tetrahydrofuran / 3 h / 0 - 20 °C

3: hydrazine / ethanol / 8 h / Reflux

4: ethylene glycol / 6 h / 165 °C

5: triethylamine / dmap / dichloromethane / 3 h / 0 °C

6: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 80 °C

7: potassium phosphate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 0.33 h / 110 °C / microwave irradiation

8: ethanol / 0.5 h / 100 °C / microwave irradiation

9: dichloromethane / 0.5 h / 100 °C / microwave irradiation

With dmap; potassium phosphate; potassium acetate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; hydrazine; dmap; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; dichloromethane; water; ethylene glycol;

Reference yield:

: 625446-22-2
4-bromo-2-fluoroacetophenone

: 1365803-29-7
N-{3-[3-(dimethylamino)propyl]-5-(trifluoromethyl)phenyl}-4-(3-methyl-1H-indazol-6-yl)phthalazin-1-amine trifluoroacetate

Guidance literature:: Multi-step reaction with 7 steps

1: hydrazine / ethanol / 8 h / Reflux

2: ethylene glycol / 6 h / 165 °C

3: triethylamine / dmap / dichloromethane / 3 h / 0 °C

4: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 80 °C

5: potassium phosphate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 0.33 h / 110 °C / microwave irradiation

6: ethanol / 0.5 h / 100 °C / microwave irradiation

7: dichloromethane / 0.5 h / 100 °C / microwave irradiation

With potassium phosphate; potassium acetate; triethylamine; hydrazine; dmap; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; ethanol; dichloromethane; water; ethylene glycol;