3-[4-amino-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamido]phenyl N,N-dimethylcarbamate

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Chemical Name:3-[4-amino-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamido]phenyl N,N-dimethylcarbamate
CAS No.:1192189-93-7
Molecular Formula:C₂₂H₂₇N₇O₃
Molecular Weight:437.501
Hs Code.:

Synonyms:3-[4-amino-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamido]phenyl N,N-dimethylcarbamate

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Chemical Property of 3-[4-amino-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamido]phenyl N,N-dimethylcarbamate

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Technology Process of 3-[4-amino-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamido]phenyl N,N-dimethylcarbamate

There total 4 articles about 3-[4-amino-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamido]phenyl N,N-dimethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1192189-95-9
3-(4-aminopiperidine-4-carboxamido)phenyl N,N-dimethylcarbamate

: 1618-36-6
4-chloro-5-methyl-7H-pyrrolo[2,3-d]pyrimidine

: 1192189-93-7
3-[4-amino-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamido]phenyl N,N-dimethylcarbamate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In isopropyl alcohol; at 120 ℃; for 18h;

Reference yield:

: 189321-65-1
1-(tert-butoxycarbonyl)-4-((tert-butoxycarbonyl)amino)piperidine-4-carboxylic acid

: 1192189-93-7
3-[4-amino-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamido]phenyl N,N-dimethylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / Isopropyl acetate / 0.25 h / 20 °C / Inert atmosphere

1.2: 1.5 h / 80 °C / Inert atmosphere

2.1: hydrogenchloride; methanol / 1,4-dioxane / 38 h / 20 °C / Inert atmosphere

3.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 18 h / 120 °C / Inert atmosphere; Sealed tube; High pressure

With hydrogenchloride; methanol; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In 1,4-dioxane; Isopropyl acetate; isopropyl alcohol;
DOI:10.1021/ml500367g

Reference yield:

: 1192189-94-8
tert-butyl 4-(tert-butoxycarbonylamino)-4-[3-(N,N-dimethylcarbamoyloxy)phenylcarbamoyl]piperidine-1-carboxylate

: 1192189-93-7
3-[4-amino-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamido]phenyl N,N-dimethylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride; methanol / 1,4-dioxane / 38 h / 20 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 18 h / 120 °C / Inert atmosphere; Sealed tube; High pressure

With hydrogenchloride; methanol; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; isopropyl alcohol;
DOI:10.1021/ml500367g