N-(t-butoxycarbonyl)-N-methoxymethylbenzylamine

Base Information

Chemical Name:N-(t-butoxycarbonyl)-N-methoxymethylbenzylamine
CAS No.:916462-72-1
Molecular Formula:C₁₄H₂₁NO₃
Molecular Weight:251.326
Hs Code.:

Synonyms:N-(t-butoxycarbonyl)-N-methoxymethylbenzylamine

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Chemical Property of N-(t-butoxycarbonyl)-N-methoxymethylbenzylamine

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Technology Process of N-(t-butoxycarbonyl)-N-methoxymethylbenzylamine

There total 1 articles about N-(t-butoxycarbonyl)-N-methoxymethylbenzylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 42116-44-9
N-tert-butoxycarbonylbenzylamine

: 107-30-2
chloromethyl methyl ether

: 916462-72-1
N-(t-butoxycarbonyl)-N-methoxymethylbenzylamine

Guidance literature:: N-tert-butoxycarbonylbenzylamine; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 0.5h;

chloromethyl methyl ether; In tetrahydrofuran; at -78 - 20 ℃;
DOI:10.1021/jo0614487

Reference yield: 67.0%

: 916462-72-1
N-(t-butoxycarbonyl)-N-methoxymethylbenzylamine

: 61550-02-5
(furan-2-yloxy)-trimethylsilane

: 916462-73-2
5-[N-benzyl-N-(t-butoxycarbonyl)aminomethyl]furan-2(5H)-one

: 3-[N-benzyl-N-(t-butoxycarbonyl)aminomethyl]furan-2(5H)-one

Guidance literature:: With trimethylsilyl trifluoromethanesulfonate; In dichloromethane; at -80 ℃; for 14h;
DOI:10.1021/jo0614487

Reference yield:

: 916462-72-1
N-(t-butoxycarbonyl)-N-methoxymethylbenzylamine

: (1RS,3SR,5RS,6SR)-7-benzyl-3-hydroxy-6-propyl-2-oxa-7-azabicyclo[3.3.0]octane

Guidance literature:: Multi-step reaction with 6 steps

1: 67 percent / trimethylsilyl triflate / CH₂Cl₂ / 14 h / -80 °C

2: 100 percent / TFA / CH₂Cl₂ / 0 - 20 °C

3: CH₂Cl₂ / 14 h / 20 °C

4: SmI₂ / 2-methyl-propan-2-ol; tetrahydrofuran / 2.5 h / -78 - 20 °C

5: H₂ / Pd/C / ethanol / 20 °C / 760 Torr

6: 85 percent / LAH / tetrahydrofuran / 1.5 h / -78 °C

With lithium aluminium tetrahydride; samarium diiodide; trimethylsilyl trifluoromethanesulfonate; hydrogen; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; tert-butyl alcohol;
DOI:10.1021/jo0614487