di-tert-butyl N-<2-fluoro-4-<(2-phthalimidoethyl)amino>benzoyl>-L-glutamate

Base Information

Chemical Name:di-tert-butyl N-<2-fluoro-4-<(2-phthalimidoethyl)amino>benzoyl>-L-glutamate
CAS No.:129175-67-3
Molecular Formula:C₃₀H₃₆FN₃O₇
Molecular Weight:569.63
Hs Code.:

Synonyms:di-tert-butyl N-<2-fluoro-4-<(2-phthalimidoethyl)amino>benzoyl>-L-glutamate

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Chemical Property of di-tert-butyl N-<2-fluoro-4-<(2-phthalimidoethyl)amino>benzoyl>-L-glutamate

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Technology Process of di-tert-butyl N-<2-fluoro-4-<(2-phthalimidoethyl)amino>benzoyl>-L-glutamate

There total 1 articles about di-tert-butyl N-<2-fluoro-4-<(2-phthalimidoethyl)amino>benzoyl>-L-glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 574-98-1
2-(2-bromoethyl)isoindoline-1,3-dione

: 85803-27-6
di-tert-butyl N-(4-amino-2-fluorobenzoyl)-L-glutamate

: 129175-67-3
di-tert-butyl N-<2-fluoro-4-<(2-phthalimidoethyl)amino>benzoyl>-L-glutamate

Guidance literature:: With 2,6-dimethylpyridine; In N,N-dimethyl acetamide; at 130 ℃; for 5h;
DOI:10.1021/jm00173a026

Reference yield: 27.0%

: 129175-67-3
di-tert-butyl N-<2-fluoro-4-<(2-phthalimidoethyl)amino>benzoyl>-L-glutamate

: 112888-43-4
4(3H)-oxo-6-(bromomethyl)-2-methyl quinazoline

: 129175-60-6
(S)-2-{4-[[2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-ethyl]-(2-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-amino]-2-fluoro-benzoylamino}-pentanedioic acid di-tert-butyl ester

Guidance literature:: With calcium carbonate; In N,N-dimethyl acetamide; at 50 ℃; for 24h;
DOI:10.1021/jm00173a026

Reference yield:

: 129175-67-3
di-tert-butyl N-<2-fluoro-4-<(2-phthalimidoethyl)amino>benzoyl>-L-glutamate

: 129175-21-9
N-(4-{N-[(3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]-N-(2-aminoethyl)amino}-2-fluorobenzoyl)-L-glutamic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 27 percent / CaCO₃ / N,N-dimethyl-acetamide / 24 h / 50 °C

2: 55 percent / 3-(dimethylamino)propylamine, N,N-diisopropylethylamine / methanol / 6 h / Heating

3: 37 percent / aq. NaOH / ethanol / 5 h

With sodium hydroxide; 1-amino-3-(dimethylamino)propane; N-ethyl-N,N-diisopropylamine; calcium carbonate; In methanol; ethanol; N,N-dimethyl acetamide;
DOI:10.1021/jm00173a026