C₁₆H₂₄O₃S₂

Base Information

• Chemical Name: C₁₆H₂₄O₃S₂
• CAS No.: 1352496-66-2
• Molecular Formula: C₁₆H₂₄O₃S₂
• Molecular Weight: 328.497
• Mol file: 1352496-66-2.mol

Synonyms:C₁₆H₂₄O₃S₂

Chemical Property of C₁₆H₂₄O₃S₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₆H₂₄O₃S₂

There total 1 articles about C₁₆H₂₄O₃S₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1,3 dithiane (505-23-7) + (2S)-2-[2-(4-methoxyphenoxy)ethyl]-2-methyloxirane (603961-40-6) → C16H24O3S2 (1352496-66-2)

Guidance literature:

1,3 dithiane; With n-butyllithium; In tetrahydrofuran; hexane; at -20 ℃; for 1h; Inert atmosphere;

(2S)-2-[2-(4-methoxyphenoxy)ethyl]-2-methyloxirane; In tetrahydrofuran; hexane; at -20 - 20 ℃; Inert atmosphere;

With ammonium chloride; In tetrahydrofuran; hexane; Inert atmosphere;

DOI:10.1016/j.tet.2011.09.011

Reference yield: 83.0%

C16H24O3S2 (1352496-66-2) + (+)-(R)S-ethynyl-p-tolylsulfoxide (99930-83-3) → C25H32O4S3 (1352496-96-8)

Guidance literature:

C₁₆H₂₄O₃S₂; With ethylmagnesium bromide; lithium chloride; In tetrahydrofuran; diethyl ether; at 20 ℃; Inert atmosphere;

(+)-(R)_S-ethynyl-p-tolylsulfoxide; In tetrahydrofuran; diethyl ether; at 20 ℃; for 12h; Inert atmosphere;

DOI:10.1016/j.tet.2011.09.011

Reference yield:

C16H24O3S2 (1352496-66-2) → C30H50O5Si (1352496-81-1)

Guidance literature:

Multi-step reaction with 10 steps

1.1: ethylmagnesium bromide; lithium chloride / tetrahydrofuran; diethyl ether / 20 °C / Inert atmosphere

1.2: 12 h / 20 °C / Inert atmosphere

2.1: water; calcium carbonate; methyl iodide / acetonitrile / 40 °C / Inert atmosphere

3.1: samarium diiodide / tetrahydrofuran; methanol / 0 °C / Inert atmosphere

4.1: di-isopropyl azodicarboxylate; triphenylphosphine / toluene / 20 °C / Inert atmosphere

5.1: methanol; potassium carbonate / 20 °C / Inert atmosphere

6.1: 2,6-dimethylpyridine / dichloromethane / 0 °C / Inert atmosphere

7.1: pyridine; trifluoroacetic anhydride / acetonitrile / 0 °C / Inert atmosphere

7.2: 0 - 20 °C / Inert atmosphere

8.1: potassium tert-butylate / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

8.2: 1 h / 0 °C / Inert atmosphere

9.1: mercury(II) diacetate; water / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

9.2: Inert atmosphere

10.1: n-butyllithium / diethyl ether; pentane / 1.17 h / -80 °C / Inert atmosphere

10.2: -80 - 20 °C / Inert atmosphere

10.3: Inert atmosphere

With pyridine; 2,6-dimethylpyridine; methanol; n-butyllithium; samarium diiodide; di-isopropyl azodicarboxylate; ethylmagnesium bromide; potassium tert-butylate; mercury(II) diacetate; water; potassium carbonate; triphenylphosphine; trifluoroacetic anhydride; calcium carbonate; lithium chloride; methyl iodide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; toluene; acetonitrile; pentane; 4.1: Mitsunobu reaction / 7.1: Pummerer rearrangement / 8.2: Wittig reaction;

DOI:10.1016/j.tet.2011.09.011

upstream raw materials:

1,3 dithiane

(2S)-2-[2-(4-methoxyphenoxy)ethyl]-2-methyloxirane

Downstream raw materials:

C₂₂H₂₆O₅S

C₂₂H₂₈O₅S

C₂₉H₃₁NO₈S

C₂₂H₂₈O₅S