[3-(tert-butyl-dimethyl-silanyloxymethyl)-4-chloro-benzyl]-(2-fluoro-ethyl)-amine

Base Information

Chemical Name:[3-(tert-butyl-dimethyl-silanyloxymethyl)-4-chloro-benzyl]-(2-fluoro-ethyl)-amine
CAS No.:946000-76-6
Molecular Formula:C₁₆H₂₇ClFNOSi
Molecular Weight:331.933
Hs Code.:

Synonyms:[3-(tert-butyl-dimethyl-silanyloxymethyl)-4-chloro-benzyl]-(2-fluoro-ethyl)-amine

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Chemical Property of [3-(tert-butyl-dimethyl-silanyloxymethyl)-4-chloro-benzyl]-(2-fluoro-ethyl)-amine

Chemical Property:

Purity/Quality:

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Technology Process of [3-(tert-butyl-dimethyl-silanyloxymethyl)-4-chloro-benzyl]-(2-fluoro-ethyl)-amine

There total 4 articles about [3-(tert-butyl-dimethyl-silanyloxymethyl)-4-chloro-benzyl]-(2-fluoro-ethyl)-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 946000-08-4
3-(((tert-butyldimethylsilyl)oxy)methyl)-4-chlorobenzaldehyde

: 460-08-2
2-fluoroethylamine hydrochloride

: 946000-76-6
[3-(tert-butyl-dimethyl-silanyloxymethyl)-4-chloro-benzyl]-(2-fluoro-ethyl)-amine

Guidance literature:: 3-(((tert-butyldimethylsilyl)oxy)methyl)-4-chlorobenzaldehyde; 2-fluoroethylamine hydrochloride; With N-ethyl-N,N-diisopropylamine; In methanol; for 4h; Heating / reflux;

With sodium tetrahydroborate; In methanol; at 20 ℃; for 1h;

With water; sodium hydrogencarbonate; In methanol;

Reference yield:

: C₁₆H₂₅ClFNOSi

: 946000-76-6
[3-(tert-butyl-dimethyl-silanyloxymethyl)-4-chloro-benzyl]-(2-fluoro-ethyl)-amine

Guidance literature:: With sodium tetrahydroborate; In methanol; at 20 ℃; for 1h;

Reference yield:

: 873782-26-4
((5-bromo-2-chlorobenzyl)oxy)(tert-butyl)dimethylsilane

: 946000-76-6
[3-(tert-butyl-dimethyl-silanyloxymethyl)-4-chloro-benzyl]-(2-fluoro-ethyl)-amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C

1.2: -78 - 20 °C

2.1: N-ethyl-N,N-diisopropylamine / methanol / 4 h / Heating / reflux

2.2: 1 h / 20 °C

With n-butyllithium; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; hexane;