(1S,2R)-1-(meta-trifluoromethylphenyl)-2,3-epoxypropan-1-ol

Base Information

• Chemical Name: (1S,2R)-1-(meta-trifluoromethylphenyl)-2,3-epoxypropan-1-ol
• CAS No.: 154902-44-0
• Molecular Formula: C₁₀H₉F₃O₂
• Molecular Weight: 218.175
• Mol file: 154902-44-0.mol

Synonyms:(1S,2R)-1-(meta-trifluoromethylphenyl)-2,3-epoxypropan-1-ol

Chemical Property of (1S,2R)-1-(meta-trifluoromethylphenyl)-2,3-epoxypropan-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1S,2R)-1-(meta-trifluoromethylphenyl)-2,3-epoxypropan-1-ol

There total 1 articles about (1S,2R)-1-(meta-trifluoromethylphenyl)-2,3-epoxypropan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

1-<3-(trifluoromethyl)phenyl>prop-2-en-1-ol (154309-48-5) → (S)-1-(meta-trifluoromethylphenyl)-2-propen-1-ol (154902-43-9) + (1S,2R)-1-(meta-trifluoromethylphenyl)-2,3-epoxypropan-1-ol (154902-44-0)

Guidance literature:

With titanium(IV) isopropylate; tert.-butylhydroperoxide; L-(+)-diisopropyl tartrate; 4 A molecular sieve; In dichloromethane; at -23 ℃; for 119h;

DOI:10.1016/S0040-4020(01)80743-2

Reference yield: 94.0%

(1S,2R)-1-(meta-trifluoromethylphenyl)-2,3-epoxypropan-1-ol (154902-44-0) → (1S,2R)-1-(meta-trifluoromethylphenyl)-1,2-propanediol

Guidance literature:

With hydrogen; Lindlar's catalyst; In ethanol; for 115h; Ambient temperature;

DOI:10.1016/S0040-4020(01)80743-2

Reference yield:

(1S,2R)-1-(meta-trifluoromethylphenyl)-2,3-epoxypropan-1-ol (154902-44-0) → 1-<3-(trifluoromethyl)phenyl>propan-1-ol (618-97-3,575433-48-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 94 percent / hydrogen / 5 percent Pd/CaCO₃ / ethanol / 115 h / Ambient temperature

2: 2 percent / hydrogen / 10 percent Pd/C / ethanol / 115 h / 70 - 75 °C

With hydrogen; palladium on activated charcoal; Lindlar's catalyst; In ethanol;

DOI:10.1016/S0040-4020(01)80743-2

upstream raw materials:

1-<3-(trifluoromethyl)phenyl>prop-2-en-1-ol

Downstream raw materials:

1-<3-(trifluoromethyl)phenyl>propan-1-ol

(R)-1-(3’-trifluoromethylphenyl)-2-propanol