(1R,2S)-2-Amino-1-[2-(3-azido-propyl)-[1,3]dioxolan-2-yl]-3-cyclohexyl-propan-1-ol

Base Information

Chemical Name:(1R,2S)-2-Amino-1-[2-(3-azido-propyl)-[1,3]dioxolan-2-yl]-3-cyclohexyl-propan-1-ol
CAS No.:134848-99-0
Molecular Formula:C₁₅H₂₈N₄O₃
Molecular Weight:312.412
Hs Code.:

Synonyms:(1R,2S)-2-Amino-1-[2-(3-azido-propyl)-[1,3]dioxolan-2-yl]-3-cyclohexyl-propan-1-ol

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Chemical Property of (1R,2S)-2-Amino-1-[2-(3-azido-propyl)-[1,3]dioxolan-2-yl]-3-cyclohexyl-propan-1-ol

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Technology Process of (1R,2S)-2-Amino-1-[2-(3-azido-propyl)-[1,3]dioxolan-2-yl]-3-cyclohexyl-propan-1-ol

There total 4 articles about (1R,2S)-2-Amino-1-[2-(3-azido-propyl)-[1,3]dioxolan-2-yl]-3-cyclohexyl-propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 134848-82-1
(4S,5R)-4-(cyclohexylmethyl)-5-<2-(3-azidopropyl)-1,3-dioxolan-2-yl>-2-oxazolidinone

: 134848-99-0
(1R,2S)-2-Amino-1-[2-(3-azido-propyl)-[1,3]dioxolan-2-yl]-3-cyclohexyl-propan-1-ol

Guidance literature:: With barium dihydroxide; In 1,4-dioxane; water; Heating;
DOI:10.1021/jm00113a005

Reference yield:

: 134848-81-0
(4S,5R)-4-(cyclohexylmethyl)-5-<2-(3-hydroxypropyl)-1,3-dioxolan-2-yl>-2-oxazolidinone

: 134848-99-0
(1R,2S)-2-Amino-1-[2-(3-azido-propyl)-[1,3]dioxolan-2-yl]-3-cyclohexyl-propan-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N / CH₂Cl₂ / 0.5 h / 0 °C

2: LiN₃ / dimethylformamide / Ambient temperature

3: 992 mg / Ba(OH)2 / dioxane; H₂O / Heating

With barium dihydroxide; lithium azide; triethylamine; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00113a005

Reference yield:

: 134848-98-9
3-[2-((4S,5R)-4-Cyclohexylmethyl-2-oxo-oxazolidin-5-yl)-[1,3]dioxolan-2-yl]-propionic acid

: 134848-99-0
(1R,2S)-2-Amino-1-[2-(3-azido-propyl)-[1,3]dioxolan-2-yl]-3-cyclohexyl-propan-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / BH₃*SMe₂ / tetrahydrofuran / 3 h / Ambient temperature

2: Et₃N / CH₂Cl₂ / 0.5 h / 0 °C

3: LiN₃ / dimethylformamide / Ambient temperature

4: 992 mg / Ba(OH)2 / dioxane; H₂O / Heating

With barium dihydroxide; lithium azide; dimethylsulfide borane complex; triethylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00113a005