(1R,2R,4R)-4-<(phenylsulfonyl)methyl>-2-methoxy-1-<oxy>cyclohexane

Base Information

Chemical Name:(1R,2R,4R)-4-<(phenylsulfonyl)methyl>-2-methoxy-1-<oxy>cyclohexane
CAS No.:127258-23-5
Molecular Formula:C₂₃H₄₀O₄SSi
Molecular Weight:440.72
Hs Code.:

(1R,2R,4R)-4-<(phenylsulfonyl)methyl>-2-methoxy-1-<<tris(methylethyl)silyl>oxy>cyclohexane

Synonyms:(1R,2R,4R)-4-<(phenylsulfonyl)methyl>-2-methoxy-1-<oxy>cyclohexane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1R,2R,4R)-4-<(phenylsulfonyl)methyl>-2-methoxy-1-<oxy>cyclohexane

Chemical Property:

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Technology Process of (1R,2R,4R)-4-<(phenylsulfonyl)methyl>-2-methoxy-1-<oxy>cyclohexane

There total 9 articles about (1R,2R,4R)-4-<(phenylsulfonyl)methyl>-2-methoxy-1-<oxy>cyclohexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 80522-42-5
triisopropylsilyl trifluoromethanesulfonate

: 127258-20-2
(1R,2R,4R)-2-methoxy-4-<(phenylsulfonyl)methyl>-1-cyclohexanol

: 127258-23-5
(1R,2R,4R)-4-<(phenylsulfonyl)methyl>-2-methoxy-1-<oxy>cyclohexane

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; at 0 ℃; for 2h;
DOI:10.1021/jo00296a040

Reference yield:

: 873-55-2
sodium benzenesulfonate

: 127258-23-5
(1R,2R,4R)-4-<(phenylsulfonyl)methyl>-2-methoxy-1-<oxy>cyclohexane

Guidance literature:: Multi-step reaction with 3 steps

1: 80 percent / dimethylformamide / 1.) 4h, RT, 2.) 30-40 deg C, 40 min

2: 1.) borane-DMS, 2.) NaOH, 30percent H₂O₂ / 1.) THF, 0 deg C, 1h, 2.) H₂O, 2h, RT

3: 75 percent / 2,6-lutidine / CH₂Cl₂ / 2 h / 0 °C

With 2,6-dimethylpyridine; sodium hydroxide; dimethylsulfide borane complex; dihydrogen peroxide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo00296a040

Reference yield:

: 127308-75-2
(1R,5R)-5-(hydroxymethyl)-2-cyclohexen-1-ol

: 127258-23-5
(1R,2R,4R)-4-<(phenylsulfonyl)methyl>-2-methoxy-1-<oxy>cyclohexane

Guidance literature:: Multi-step reaction with 7 steps

1: 80 percent / imidazole / dimethylformamide / 5 h / Ambient temperature

2: 100 percent / NaH / tetrahydrofuran / 4.5 h / Ambient temperature

3: 48percent aq. HF / diethyl ether; acetonitrile / 23 h

4: 75 percent / triphenylphosphine, imidazol, iodine / benzene / 1 h / Heating

5: 80 percent / dimethylformamide / 1.) 4h, RT, 2.) 30-40 deg C, 40 min

6: 1.) borane-DMS, 2.) NaOH, 30percent H₂O₂ / 1.) THF, 0 deg C, 1h, 2.) H₂O, 2h, RT

7: 75 percent / 2,6-lutidine / CH₂Cl₂ / 2 h / 0 °C

With 1H-imidazole; 2,6-dimethylpyridine; sodium hydroxide; dimethylsulfide borane complex; hydrogen fluoride; dihydrogen peroxide; iodine; sodium hydride; triphenylphosphine; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide; acetonitrile; benzene;
DOI:10.1021/jo00296a040