(4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-3-((2-(6-isopropyl-3-methoxypyridin-2-yl)-5,5-dimethylcyclohex-1-enyl)methyl)-4-methyloxazolidin-2-one

Base Information

Chemical Name:(4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-3-((2-(6-isopropyl-3-methoxypyridin-2-yl)-5,5-dimethylcyclohex-1-enyl)methyl)-4-methyloxazolidin-2-one
CAS No.:1402798-87-1
Molecular Formula:C₃₀H₃₄F₆N₂O₃
Molecular Weight:584.602
Hs Code.:

Synonyms:(4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-3-((2-(6-isopropyl-3-methoxypyridin-2-yl)-5,5-dimethylcyclohex-1-enyl)methyl)-4-methyloxazolidin-2-one

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Chemical Property of (4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-3-((2-(6-isopropyl-3-methoxypyridin-2-yl)-5,5-dimethylcyclohex-1-enyl)methyl)-4-methyloxazolidin-2-one

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Technology Process of (4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-3-((2-(6-isopropyl-3-methoxypyridin-2-yl)-5,5-dimethylcyclohex-1-enyl)methyl)-4-methyloxazolidin-2-one

There total 10 articles about (4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-3-((2-(6-isopropyl-3-methoxypyridin-2-yl)-5,5-dimethylcyclohex-1-enyl)methyl)-4-methyloxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.1%

: 1423047-55-5
C₃₀H₃₄F₆N₂O₄

: 1402798-87-1
(4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-3-((2-(6-isopropyl-3-methoxypyridin-2-yl)-5,5-dimethylcyclohex-1-enyl)methyl)-4-methyloxazolidin-2-one

Guidance literature:: With indium; ammonium chloride; In ethanol; at 80 ℃;

Reference yield:

: 321535-37-9
2-bromo-6-iodo-3-methoxypyridine

: 1402798-87-1
(4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-3-((2-(6-isopropyl-3-methoxypyridin-2-yl)-5,5-dimethylcyclohex-1-enyl)methyl)-4-methyloxazolidin-2-one

Guidance literature:: Multi-step reaction with 9 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / Heating

2: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride

3: hydrogen / palladium on activated charcoal / methanol

4: 3-chloro-benzenecarboperoxoic acid / dichloromethane

5: diisobutylaluminium hydride

6: Dess-Martin periodane / dichloromethane

7: sodium cyanoborohydride; acetic acid / dichloromethane / 20 °C

8: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C

9: indium; ammonium chloride / ethanol / 80 °C

With indium; hydrogen; diisobutylaluminium hydride; sodium cyanoborohydride; sodium carbonate; ammonium chloride; Dess-Martin periodane; acetic acid; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium on activated charcoal; In methanol; 1,2-dimethoxyethane; ethanol; dichloromethane; water;

Reference yield:

: 6602-32-0
2-bromo-pyridin-3-ol

: 1402798-87-1
(4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-3-((2-(6-isopropyl-3-methoxypyridin-2-yl)-5,5-dimethylcyclohex-1-enyl)methyl)-4-methyloxazolidin-2-one

Guidance literature:: Multi-step reaction with 11 steps

1: potassium carbonate; iodine / water

2: caesium carbonate

3: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / Heating

4: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride

5: hydrogen / palladium on activated charcoal / methanol

6: 3-chloro-benzenecarboperoxoic acid / dichloromethane

7: diisobutylaluminium hydride

8: Dess-Martin periodane / dichloromethane

9: sodium cyanoborohydride; acetic acid / dichloromethane / 20 °C

10: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C

11: indium; ammonium chloride / ethanol / 80 °C

With indium; hydrogen; iodine; diisobutylaluminium hydride; sodium cyanoborohydride; sodium carbonate; potassium carbonate; ammonium chloride; caesium carbonate; Dess-Martin periodane; acetic acid; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium on activated charcoal; In methanol; 1,2-dimethoxyethane; ethanol; dichloromethane; water;