tert-butyl (3S)-3-{4-[2-(7-cyano-2-naphthyl)ethyl]phenoxy}-1-pyrrolidinecarboxylate

Base Information

Chemical Name:tert-butyl (3S)-3-{4-[2-(7-cyano-2-naphthyl)ethyl]phenoxy}-1-pyrrolidinecarboxylate
CAS No.:859140-00-4
Molecular Formula:C₂₈H₃₀N₂O₃
Molecular Weight:442.558
Hs Code.:

Synonyms:tert-butyl (3S)-3-{4-[2-(7-cyano-2-naphthyl)ethyl]phenoxy}-1-pyrrolidinecarboxylate

Suppliers and Price of tert-butyl (3S)-3-{4-[2-(7-cyano-2-naphthyl)ethyl]phenoxy}-1-pyrrolidinecarboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tert-butyl (3S)-3-{4-[2-(7-cyano-2-naphthyl)ethyl]phenoxy}-1-pyrrolidinecarboxylate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of tert-butyl (3S)-3-{4-[2-(7-cyano-2-naphthyl)ethyl]phenoxy}-1-pyrrolidinecarboxylate

There total 3 articles about tert-butyl (3S)-3-{4-[2-(7-cyano-2-naphthyl)ethyl]phenoxy}-1-pyrrolidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: tert-butyl (3S)-3-{4-[2-(7-cyano-2-naphthyl)ethenyl]phenoxy}-1-pyrrolidinecarboxylate

: 859140-00-4
tert-butyl (3S)-3-{4-[2-(7-cyano-2-naphthyl)ethyl]phenoxy}-1-pyrrolidinecarboxylate

Guidance literature:: With hydrogen; palladium on activated charcoal; In tetrahydrofuran; ethanol; at 20 ℃; under 760 Torr;
DOI:10.1016/j.bmc.2005.04.006

Reference yield:

: 150613-54-0
4-<<(3S)-1-(tert-butoxycarbonyl)-3-pyrrolidinyl>oxy>benzaldehyde

: 859140-00-4
tert-butyl (3S)-3-{4-[2-(7-cyano-2-naphthyl)ethyl]phenoxy}-1-pyrrolidinecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran; ethanol / 19.5 h / 20 °C

2: 3.53 g / hydrogen / Pd/C / tetrahydrofuran; ethanol / 20 °C / 760 Torr

With hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; palladium on activated charcoal; In tetrahydrofuran; ethanol; 1: Wittig reaction;
DOI:10.1016/j.bmc.2005.04.006

Reference yield:

: <(7-cyano-2-naphthyl)methyl>triphenylphosphonium bromide

: 859140-00-4
tert-butyl (3S)-3-{4-[2-(7-cyano-2-naphthyl)ethyl]phenoxy}-1-pyrrolidinecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran; ethanol / 19.5 h / 20 °C

2: 3.53 g / hydrogen / Pd/C / tetrahydrofuran; ethanol / 20 °C / 760 Torr

With hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; palladium on activated charcoal; In tetrahydrofuran; ethanol; 1: Wittig reaction;
DOI:10.1016/j.bmc.2005.04.006