8-(3,4-dimethoxybenzyl)-2,2-dimethyl-8,9-dihydro-[1,3]dioxino[4,5-e]isoindol-7(4H)-one

Base Information

Chemical Name:8-(3,4-dimethoxybenzyl)-2,2-dimethyl-8,9-dihydro-[1,3]dioxino[4,5-e]isoindol-7(4H)-one
CAS No.:1236125-65-7
Molecular Formula:C₂₂H₂₅NO₆
Molecular Weight:399.444
Hs Code.:

Synonyms:8-(3,4-dimethoxybenzyl)-2,2-dimethyl-8,9-dihydro-[1,3]dioxino[4,5-e]isoindol-7(4H)-one

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Chemical Property of 8-(3,4-dimethoxybenzyl)-2,2-dimethyl-8,9-dihydro-[1,3]dioxino[4,5-e]isoindol-7(4H)-one

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Technology Process of 8-(3,4-dimethoxybenzyl)-2,2-dimethyl-8,9-dihydro-[1,3]dioxino[4,5-e]isoindol-7(4H)-one

There total 10 articles about 8-(3,4-dimethoxybenzyl)-2,2-dimethyl-8,9-dihydro-[1,3]dioxino[4,5-e]isoindol-7(4H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1236125-62-4
5-methoxy-2,2-dimethyl-8,9-dihydro-[1,3]dioxino[4,5-e]isoindol-7(4H)-one

: 7306-46-9
4-chloromethyl-1,2-dimethoxy-benzene

: 1236125-65-7
8-(3,4-dimethoxybenzyl)-2,2-dimethyl-8,9-dihydro-[1,3]dioxino[4,5-e]isoindol-7(4H)-one

Guidance literature:: 5-methoxy-2,2-dimethyl-8,9-dihydro-[1,3]dioxino[4,5-e]isoindol-7(4H)-one; With sodium hexamethyldisilazane; tetra-(n-butyl)ammonium iodide; In tetrahydrofuran; at 0 ℃; Inert atmosphere;

4-chloromethyl-1,2-dimethoxy-benzene; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1039/c000193g

Reference yield:

: 1310461-17-6
methyl 8-aminomethyl-5-methoxy-2,2-dimethyl-4H-benzo[d][1,3]dioxine-7carboxylate hydrochloride salt

: 1236125-65-7
8-(3,4-dimethoxybenzyl)-2,2-dimethyl-8,9-dihydro-[1,3]dioxino[4,5-e]isoindol-7(4H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: sodium methylate / methanol / 1 h / 20 °C

2: sodium hexamethyldisilazane; tetra-(n-butyl)ammonium iodide / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

With sodium methylate; sodium hexamethyldisilazane; tetra-(n-butyl)ammonium iodide; In tetrahydrofuran; methanol;
DOI:10.1002/ejoc.201100173

Reference yield:

: 1236125-57-7
methyl 8-cyano-5-methoxy-2,2-dimethyl-4H-benzo[d][1,3]dioxine-7-carboxylate

: 1236125-65-7
8-(3,4-dimethoxybenzyl)-2,2-dimethyl-8,9-dihydro-[1,3]dioxino[4,5-e]isoindol-7(4H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: platinum(IV) oxide; hydrogen / ethanol; chloroform / 48 h / 20 °C

2: sodium methylate / methanol / 1 h / 20 °C

3: sodium hexamethyldisilazane; tetra-(n-butyl)ammonium iodide / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

With platinum(IV) oxide; hydrogen; sodium methylate; sodium hexamethyldisilazane; tetra-(n-butyl)ammonium iodide; In tetrahydrofuran; methanol; ethanol; chloroform;
DOI:10.1002/ejoc.201100173