Technology Process of (+/-)-6-benzyloxy-7-methoxy-2-(3-methoxybenzyl)-3-methyl-1,2,3,4-tetrahydroisoquinoline
There total 6 articles about (+/-)-6-benzyloxy-7-methoxy-2-(3-methoxybenzyl)-3-methyl-1,2,3,4-tetrahydroisoquinoline which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: nickel; hydrazine / methanol / 18 h / 0 - 40 °C
2: triethylamine / dichloromethane / 24 h / 0 - 20 °C
3: toluene-4-sulfonic acid / toluene / 22 h / 120 °C
4: water; potassium hydroxide / ethanol / 66 h / 120 °C
5: triethylamine / ethanol / 1.5 h / 130 °C / Microwave irradiation
With
water; nickel; toluene-4-sulfonic acid; triethylamine; potassium hydroxide; hydrazine;
In
methanol; ethanol; dichloromethane; toluene;
DOI:10.1021/ml200232c
- Guidance literature:
-
Multi-step reaction with 6 steps
1: sodium tetrahydroborate / tetrahydrofuran; ethanol / 2 h / 0 - 20 °C
2: nickel; hydrazine / methanol / 18 h / 0 - 40 °C
3: triethylamine / dichloromethane / 24 h / 0 - 20 °C
4: toluene-4-sulfonic acid / toluene / 22 h / 120 °C
5: water; potassium hydroxide / ethanol / 66 h / 120 °C
6: triethylamine / ethanol / 1.5 h / 130 °C / Microwave irradiation
With
sodium tetrahydroborate; water; nickel; toluene-4-sulfonic acid; triethylamine; potassium hydroxide; hydrazine;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; toluene;
DOI:10.1021/ml200232c
- Guidance literature:
-
Multi-step reaction with 7 steps
1: ammonium acetate / 22 h / 120 °C
2: sodium tetrahydroborate / tetrahydrofuran; ethanol / 2 h / 0 - 20 °C
3: nickel; hydrazine / methanol / 18 h / 0 - 40 °C
4: triethylamine / dichloromethane / 24 h / 0 - 20 °C
5: toluene-4-sulfonic acid / toluene / 22 h / 120 °C
6: water; potassium hydroxide / ethanol / 66 h / 120 °C
7: triethylamine / ethanol / 1.5 h / 130 °C / Microwave irradiation
With
sodium tetrahydroborate; ammonium acetate; water; nickel; toluene-4-sulfonic acid; triethylamine; potassium hydroxide; hydrazine;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; toluene;
1: Henry reaction;
DOI:10.1021/ml200232c
