2-hydroxy-3-(2-methoxy-phenoxy)-N-methyl-3-phenyl propanamine hydrochloride

Base Information

Chemical Name:2-hydroxy-3-(2-methoxy-phenoxy)-N-methyl-3-phenyl propanamine hydrochloride
CAS No.:71621-52-8
Molecular Formula:C₁₇H₂₁NO₃*ClH
Molecular Weight:323.82
Hs Code.:

Synonyms:2-hydroxy-3-(2-methoxy-phenoxy)-N-methyl-3-phenyl propanamine hydrochloride

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Chemical Property of 2-hydroxy-3-(2-methoxy-phenoxy)-N-methyl-3-phenyl propanamine hydrochloride

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Technology Process of 2-hydroxy-3-(2-methoxy-phenoxy)-N-methyl-3-phenyl propanamine hydrochloride

There total 13 articles about 2-hydroxy-3-(2-methoxy-phenoxy)-N-methyl-3-phenyl propanamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 93886-47-6
N-ethoxycarbonyl-2-hydroxy-3-(2-methoxy-phenoxy)-3-phenylpropanamine

: 71621-52-8
2-hydroxy-3-(2-methoxy-phenoxy)-N-methyl-3-phenyl propanamine hydrochloride

Guidance literature:: With hydrogenchloride; lithium aluminium tetrahydride; In diethyl ether; for 16h; Ambient temperature;

Reference yield:

: 10606-73-2,99531-04-1,116836-53-4,4773-33-5
ethyl 2-chloro-2-phenylacetate

: 71621-52-8
2-hydroxy-3-(2-methoxy-phenoxy)-N-methyl-3-phenyl propanamine hydrochloride

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) NaH / 1.) dimethylacetamide, 1-1.5 h, 40 deg C; 2.) dimethylacetamide, 5 h, 90 deg C

2: KOH / methanol / 20 h / Ambient temperature

3: SOCl₂ / 16 h / Ambient temperature

4: LiAlH(O-tBu)3 / bis-(2-methoxy-ethyl) ether / 0.5 h / -60 °C

5: 1.) Na₂S₂O₅; 2.) KCN / 1.) H₂O, EtOH, 16 h, 55 deg C; 2.) H₂O, EtOH, 7 h, reflux

6: LiAlH₄ / diethyl ether; tetrahydrofuran / also with BH₃; 1.) 16 h, RT; 2.) 1 h, 40 deg C

7: 95 percent / NaOH / CHCl₃

8: 85 percent / LiAlH₄, HCl / diethyl ether / 16 h / Ambient temperature

With hydrogenchloride; potassium cyanide; sodium metabisulfite; potassium hydroxide; sodium hydroxide; lithium aluminium tetrahydride; thionyl chloride; sodium hydride; lithium tri-t-butoxyaluminum hydride; In tetrahydrofuran; methanol; diethyl ether; chloroform; diethylene glycol dimethyl ether;

Reference yield:

: 90-05-1
2-methoxy-phenol

: 71621-52-8
2-hydroxy-3-(2-methoxy-phenoxy)-N-methyl-3-phenyl propanamine hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) NaH / 1.) dimethylacetamide, 1-1.5 h, 40 deg C; 2.) dimethylacetamide, 5 h, 90 deg C

2: KOH / methanol / 20 h / Ambient temperature

3: 1.) carbonyl-diimidazole; 2.) nitromethane Na salt / 1.) THF, reflux, 1 h; 2.) THF, reflux, 16 h

4: 72 percent / H₂, H₂SO₄ / PtO₂ / acetic acid / 0.67 h / 1900 Torr

5: 95 percent / NaOH / CHCl₃

6: 85 percent / LiAlH₄, HCl / diethyl ether / 16 h / Ambient temperature

With hydrogenchloride; potassium hydroxide; sodium hydroxide; lithium aluminium tetrahydride; Carbonyldiimidazole; sulfuric acid; hydrogen; sodium nitromethane; sodium hydride; platinum(IV) oxide; In methanol; diethyl ether; chloroform; acetic acid;