N-[2-(2-bromophenyl)ethyl]-N-[1-methyl-2-(phenylsulfinyl)ethyl]-2,2-dimethylpropionamide

Base Information

• Chemical Name: N-[2-(2-bromophenyl)ethyl]-N-[1-methyl-2-(phenylsulfinyl)ethyl]-2,2-dimethylpropionamide
• CAS No.: 848772-82-7
• Molecular Formula: C₂₂H₂₈BrNO₂S
• Molecular Weight: 450.44
• Mol file: 848772-82-7.mol

Synonyms:N-[2-(2-bromophenyl)ethyl]-N-[1-methyl-2-(phenylsulfinyl)ethyl]-2,2-dimethylpropionamide

Chemical Property of N-[2-(2-bromophenyl)ethyl]-N-[1-methyl-2-(phenylsulfinyl)ethyl]-2,2-dimethylpropionamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[2-(2-bromophenyl)ethyl]-N-[1-methyl-2-(phenylsulfinyl)ethyl]-2,2-dimethylpropionamide

There total 5 articles about N-[2-(2-bromophenyl)ethyl]-N-[1-methyl-2-(phenylsulfinyl)ethyl]-2,2-dimethylpropionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

N-[2-(2-bromophenyl)ethyl]-N-(1-methyl-2-(phenylthio)ethyl)trimethylacetamide (848772-60-1) → N-[2-(2-bromophenyl)ethyl]-N-[1-methyl-2-(phenylsulfinyl)ethyl]-2,2-dimethylpropionamide (848772-82-7)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 ℃;

DOI:10.1021/jo040264u

Reference yield:

N-[2-(2-bromophenyl)ethyl]-1-methyl-2-(phenylthio)ethylamine (848772-43-0) → N-[2-(2-bromophenyl)ethyl]-N-[1-methyl-2-(phenylsulfinyl)ethyl]-2,2-dimethylpropionamide (848772-82-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / Et₃N / CH₂Cl₂ / 0 °C

2: 83 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 0 °C

With triethylamine; 3-chloro-benzenecarboperoxoic acid; In dichloromethane;

DOI:10.1021/jo040264u

Reference yield:

2-(2-bromophenyl)-N-(1-methyl-2-(phenylthio)ethyl)acetamide → N-[2-(2-bromophenyl)ethyl]-N-[1-methyl-2-(phenylsulfinyl)ethyl]-2,2-dimethylpropionamide (848772-82-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: BH₃*THF / tetrahydrofuran / 1.5 h / Heating

1.2: 97 percent / aq.HCl / 1 h / Heating

2.1: 100 percent / Et₃N / CH₂Cl₂ / 0 °C

3.1: 83 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 0 °C

With borane-THF; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jo040264u

upstream raw materials:

N-[2-(2-bromophenyl)ethyl]-N-(1-methyl-2-(phenylthio)ethyl)trimethylacetamide

N-[2-(2-bromophenyl)ethyl]-1-methyl-2-(phenylthio)ethylamine

N-(2-phenylthioethyl)-N-methyl-amine

ortho-bromophenylacetic acid

Downstream raw materials:

N-[2-(2-bromophenyl)ethyl]-N-(1-methylethenyl)-2,2-dimethylpropionamide

Refernces