1-[7-chloro-2-(3-methoxyphenyl)pyrazolo[1,5-a]pyridin-3-yl]-2-propyn-1-ol

Base Information

Chemical Name:1-[7-chloro-2-(3-methoxyphenyl)pyrazolo[1,5-a]pyridin-3-yl]-2-propyn-1-ol
CAS No.:460079-71-4
Molecular Formula:C₁₇H₁₃ClN₂O₂
Molecular Weight:312.755
Hs Code.:

Synonyms:1-[7-chloro-2-(3-methoxyphenyl)pyrazolo[1,5-a]pyridin-3-yl]-2-propyn-1-ol

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Chemical Property of 1-[7-chloro-2-(3-methoxyphenyl)pyrazolo[1,5-a]pyridin-3-yl]-2-propyn-1-ol

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Technology Process of 1-[7-chloro-2-(3-methoxyphenyl)pyrazolo[1,5-a]pyridin-3-yl]-2-propyn-1-ol

There total 6 articles about 1-[7-chloro-2-(3-methoxyphenyl)pyrazolo[1,5-a]pyridin-3-yl]-2-propyn-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 460079-70-3
7-chloro-2-(3-methoxyphenyl)pyrazolo[1,5-a]pyridine-3-carbaldehyde

: 4301-14-8
acetylenemagnesium bromide

: 460079-71-4
1-[7-chloro-2-(3-methoxyphenyl)pyrazolo[1,5-a]pyridin-3-yl]-2-propyn-1-ol

Guidance literature:: In tetrahydrofuran; at -78 - 0 ℃;
DOI:10.1016/j.bmc.2005.05.043

Reference yield:

: 460079-69-0
7-chloro-2-(3-methoxyphenyl)pyrazolo[1,5-a]pyridine

: 460079-71-4
1-[7-chloro-2-(3-methoxyphenyl)pyrazolo[1,5-a]pyridin-3-yl]-2-propyn-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 75 percent / POCl₃ / 0 - 20 °C

2: 100 percent / tetrahydrofuran / -78 - 0 °C

With trichlorophosphate; In tetrahydrofuran; 1: Vilsmeier-Haack formylation / 2: Grignard reaction;
DOI:10.1016/j.bmc.2005.05.043

Reference yield:

: 460079-84-9
2-(6-chloro-2-pyridinyl)-1-(3-methoxyphenyl)ethanone

: 460079-71-4
1-[7-chloro-2-(3-methoxyphenyl)pyrazolo[1,5-a]pyridin-3-yl]-2-propyn-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydroxylamine hydrochloride; NaOH / methanol; H₂O / Heating

2.1: frifluoroacetic anhydride; triethylamine / 1,2-dimethoxy-ethane / 0 - 20 °C

2.2: 75 percent / iron(II) chloride / 1,2-dimethoxy-ethane / 8 h / Heating

3.1: 75 percent / POCl₃ / 0 - 20 °C

4.1: 100 percent / tetrahydrofuran / -78 - 0 °C

With sodium hydroxide; hydroxylamine hydrochloride; triethylamine; trifluoroacetic anhydride; trichlorophosphate; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; water; 3.1: Vilsmeier-Haack formylation / 4.1: Grignard reaction;
DOI:10.1016/j.bmc.2005.05.043