(3S)-3-[5-(2-[¹⁸F]fluoroethoxy)phenyl]-3-[({(3R)-1-[3-(piperidin-4-yl)propanoyl]piperidin-3-yl}carbonyl)amino]propanoic acid

Base Information

• Chemical Name: (3S)-3-[5-(2-[¹⁸F]fluoroethoxy)phenyl]-3-[({(3R)-1-[3-(piperidin-4-yl)propanoyl]piperidin-3-yl}carbonyl)amino]propanoic acid
• CAS No.: 1423134-52-4
• Molecular Formula: C₃₀H₃₉FN₄O₅
• Molecular Weight: 553.663
• Mol file: 1423134-52-4.mol

Synonyms:(3S)-3-[5-(2-[¹⁸F]fluoroethoxy)phenyl]-3-[({(3R)-1-[3-(piperidin-4-yl)propanoyl]piperidin-3-yl}carbonyl)amino]propanoic acid

Chemical Property of (3S)-3-[5-(2-[¹⁸F]fluoroethoxy)phenyl]-3-[({(3R)-1-[3-(piperidin-4-yl)propanoyl]piperidin-3-yl}carbonyl)amino]propanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3S)-3-[5-(2-[¹⁸F]fluoroethoxy)phenyl]-3-[({(3R)-1-[3-(piperidin-4-yl)propanoyl]piperidin-3-yl}carbonyl)amino]propanoic acid

There total 13 articles about (3S)-3-[5-(2-[¹⁸F]fluoroethoxy)phenyl]-3-[({(3R)-1-[3-(piperidin-4-yl)propanoyl]piperidin-3-yl}carbonyl)amino]propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl 4-{3-[(3R)-3-{[3-methoxy-1-{5-[4-(2-{[(4-methylphenyl)sulfonyl]oxy}ethoxy)phenyl]pyridin-3-yl}-3-oxopropyl]carbamoyl}piperidin-1-yl]-3-oxopropyl}piperidine-1-carboxylate → (3S)-3-[5-(2-[18F]fluoroethoxy)phenyl]-3-[({(3R)-1-[3-(piperidin-4-yl)propanoyl]piperidin-3-yl}carbonyl)amino]propanoic acid (1423134-52-4)

Guidance literature:

With K₁₈F*C₁₈H₃₆N₂O₆; sodium hydroxide; In acetonitrile; at 25 - 100 ℃; for 0.5h; Sealed tube; Inert atmosphere;

Reference yield:

tert-butyl 4-{3-[(3R)-3-{[(1S)-3-tert-butoxy-1-{5-[4-(2-{[(4-methylphenyl)sulfonyl]oxy}ethoxy)phenyl]pyridin-3-yl}-3-oxopropyl]carbamoyl}piperidin-1-yl]-3-oxopropyl}piperidine-1-carboxylate (1423134-38-6) → (3S)-3-[5-(2-[18F]fluoroethoxy)phenyl]-3-[({(3R)-1-[3-(piperidin-4-yl)propanoyl]piperidin-3-yl}carbonyl)amino]propanoic acid (1423134-52-4)

Guidance literature:

With hydrogenchloride; Cs₁₈F*C₁₈H₃₆N₂O₆; In water; acetonitrile; at 100 ℃; for 0.416667h; Sealed tube; Inert atmosphere;

Reference yield:

tert-butyl 4-[3-((3R)-3-{[(1S)-1-(5-bromopyridin-3-yl)-3-tert-butoxy-3-oxopropyl]carbamoyl}piperidin-1-yl)-3-oxopropyl]piperidine-1-carboxylate (1423135-32-3) → (3S)-3-[5-(2-[18F]fluoroethoxy)phenyl]-3-[({(3R)-1-[3-(piperidin-4-yl)propanoyl]piperidin-3-yl}carbonyl)amino]propanoic acid (1423134-52-4)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium fluoride / water; toluene; ethanol / 4 h / 100 °C

2: caesium carbonate / N,N-dimethyl-formamide / 21 h / 5 - 20 °C

3: Cs₁₈F*C₁₈H₃₆N₂O₆; hydrogenchloride / water; acetonitrile / 0.42 h / 100 °C / Sealed tube; Inert atmosphere

With hydrogenchloride; potassium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; Cs₁₈F*C₁₈H₃₆N₂O₆; caesium carbonate; In ethanol; water; N,N-dimethyl-formamide; toluene; acetonitrile;

upstream raw materials:

tert-butyl 4-[3-((3R)-3-{[(1S)-1-(5-bromopyridin-3-yl)-3-tert-butoxy-3-oxopropyl]carbamoyl}piperidin-1-yl)-3-oxopropyl]piperidine-1-carboxylate

tert-butyl 3-amino-3-[5-bromopyridin-3-yl]prop-2-enoate

tert-butyl (3S)-3-amino-3-[5-bromopyridin-3-yl]propanoate

tert-butyl 4-{3-[(3R)-3-{[(1S)-3-tert-butoxy-1-{5-[4-hydroxyphenyl]pyridin-3-yl}-3-oxopropyl]carbamoyl}piperidin-1-yl]-3-oxopropyl}piperidine-1-carboxylate