kijanimicin

Base Information

• Chemical Name: kijanimicin
• CAS No.: 78798-08-0
• Molecular Formula: C₆₇H₁₀₀N₂O₂₄
• Molecular Weight: 1317.53
• Mol file: 78798-08-0.mol

Synonyms:Kijanimicin;18H-16a,19-Metheno-16aH-benzo[b]naphth[2,1-j]oxacyclotetradecin, kijanimicinderiv.; NSC 329515

Chemical Property of kijanimicin

Chemical Property:

• PKA: 4.50±1.00(Predicted)
• PSA: 350.43000
• Density: 1.35±0.1 g/cm3(Predicted)
• LogP: 6.36800

Purity/Quality:

>99% by HPLC ^*data from raw suppliers

Kijanimicin ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Kijanimicin is a tetronic acid related to saccharocarcin, chlorothricin, versipelostatin and tetrocarcin. Like the tetrocarcins, kijanimicin contains an unusual nitroaminoglycoside. Kijanimicin is a potent antibacterial, antimalarial and antitumour active. Several members of this class have received considerable literature focus. Versipelostatin inhibits transcription from the promoter of GRP78, a gene that is activated as part of a stress signalling pathway under glucose deprivation resulting in unfolded protein response (UPR). The UPR-inhibitory action is seen only in conditions of glucose deprivation and causes selective and massive killing of the glucose-deprived cells. Tetrocarcin A appears to target the phosphatidylinositide-3'-kinase/Akt signalling pathway. Kijanimicin is an antibacterial tetronic acid compound.

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