4-(4-((2,8-dimethyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)methyl)piperazin-1-yl)-N-ethyl-3-methylbenzamide

Base Information

Chemical Name:4-(4-((2,8-dimethyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)methyl)piperazin-1-yl)-N-ethyl-3-methylbenzamide
CAS No.:1246085-28-8
Molecular Formula:C₂₅H₃₂N₄O₃
Molecular Weight:436.554
Hs Code.:

Synonyms:4-(4-((2,8-dimethyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)methyl)piperazin-1-yl)-N-ethyl-3-methylbenzamide

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Chemical Property of 4-(4-((2,8-dimethyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)methyl)piperazin-1-yl)-N-ethyl-3-methylbenzamide

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Technology Process of 4-(4-((2,8-dimethyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)methyl)piperazin-1-yl)-N-ethyl-3-methylbenzamide

There total 9 articles about 4-(4-((2,8-dimethyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)methyl)piperazin-1-yl)-N-ethyl-3-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: N-ethyl-3-methyl-4-(piperazin-1-yl)benzamide hydrochloride

: 1246081-94-6
2,8-dimethyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-6-carbaldehyde

: 1246085-28-8
4-(4-((2,8-dimethyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)methyl)piperazin-1-yl)-N-ethyl-3-methylbenzamide

Guidance literature:: With sodium tris(acetoxy)borohydride; acetic acid; In 1,2-dichloro-ethane; at 23 ℃; for 18h;
DOI:10.1016/j.bmcl.2013.06.055

Reference yield:

: 185147-08-4
4-fluoro-3-methylbenzonitrile

: 1246085-28-8
4-(4-((2,8-dimethyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)methyl)piperazin-1-yl)-N-ethyl-3-methylbenzamide

Guidance literature:: Multi-step reaction with 6 steps

1: dimethyl sulfoxide / 16 h / 140 °C

2: tetrahydrofuran; methanol / 18.25 h / 10 - 23 °C

3: sodium hydroxide / ethanol; water / 10 h / 90 °C

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / N,N-dimethyl-formamide / 2 h / 20 °C

5: hydrogenchloride / 1,4-dioxane / 0.5 h

6: sodium tris(acetoxy)borohydride; acetic acid / 1,2-dichloro-ethane / 18 h / 23 °C

With 4-methyl-morpholine; hydrogenchloride; sodium tris(acetoxy)borohydride; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water; dimethyl sulfoxide; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2013.06.055

Reference yield:

: 851000-31-2
tert-butyl 4-(4-cyano-2-methylphenyl)piperazine-1-carboxylate

: 1246085-28-8
4-(4-((2,8-dimethyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)methyl)piperazin-1-yl)-N-ethyl-3-methylbenzamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydroxide / ethanol; water / 10 h / 90 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / N,N-dimethyl-formamide / 2 h / 20 °C

3: hydrogenchloride / 1,4-dioxane / 0.5 h

4: sodium tris(acetoxy)borohydride; acetic acid / 1,2-dichloro-ethane / 18 h / 23 °C

With 4-methyl-morpholine; hydrogenchloride; sodium tris(acetoxy)borohydride; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In 1,4-dioxane; ethanol; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2013.06.055