Tris(2-carboxyethyl)phosphine hydrochloride

Base Information

• Chemical Name: Tris(2-carboxyethyl)phosphine hydrochloride
• CAS No.: 51805-45-9
• Molecular Formula: C9H15O6P^.HCl
• Molecular Weight: 286.649
• Hs Code.: 29319090
• European Community (EC) Number: 629-759-1
• UNII: H49AAM893K
• DSSTox Substance ID: DTXSID10370367
• Wikidata: Q27279627
• ChEMBL ID: CHEMBL2047686
• Mol file: 51805-45-9.mol

Synonyms:51805-45-9;Tris(2-carboxyethyl)phosphine hydrochloride;TCEP Hydrochloride;TCEP HCl;3,3',3''-Phosphinetriyltripropanoic acid hydrochloride;Tris(2-carboxyethyl)phosphine, HCl;TCEP (hydrochloride);Tcep hydrochloride [MI];MFCD00145469;tris-(2-carboxyethyl)phosphine hydrochloride;UNII-H49AAM893K;Tris(carboxyethyl)phosphine hydrochloride;H49AAM893K;3-[bis(2-carboxyethyl)phosphanyl]propanoic acid;hydrochloride;Propanoic acid, 3,3',3''-phosphinidynetris-, hydrochloride;TRIS(2-CARBOXYETHYL)PHOSPHINE HCL;Propanoic acid, 3,3',3''-phosphinylidynetris-, hydrochloride (1:1);CHEMBL2047686;TCEP, Hydrochloride;TCEP-HCl;3-[bis(2-carboxyethyl)phosphanyl]propanoic acid hydrochloride;C9H16ClO6P;SCHEMBL61373;P(CH2CH2CO2H)3.HCl;DTXSID10370367;PBVAJRFEEOIAGW-UHFFFAOYSA-N;AMY39300;BCP27832;s4611;AKOS016008718;CS-O-11284;CS-W012216;HY-W011500;Tris-carboxyethylphosphine hydrochloride;AS-19130;SY010484;tri(2-carboxyethyl)phosphine hydrochloride;tris(2-carboxyethyl)phosphine-hydrochloride;FT-0657850;T1656;3,3',3''-Phosphinetriyltripropanoic acid HCl;C-1818;M02624;M02706;EN300-1724932;TRIS(2-CARBOXYETHYL)PHOSPHINEHYDROCHLORIDE;Tris(2-carboxyethyl)phosphine hydrochloride (1:1);Q27279627;3,3',3''-Phosphinetriyl-tripropionic acid hydrochloride;Z1741982651;TCEP*HCl;TRIS(2-CARBOXYETHYL)PHOSPHINE HYDROCHLORIDE;Tris(2-carboxyethyl)phosphine hydrochloride, powder, >=98%;Tris(2-carboxyethyl)phosphine hydrochloride, BioUltra, >=98% (NMR);Tris(2-carboxyethyl)phosphine hydrochloride, purum, >=98.0% (C);Tris(2-carboxyethyl)phosphine hydrochloride, BioUltra, for electrophoresis, SDS-PAGE tested

Chemical Property of Tris(2-carboxyethyl)phosphine hydrochloride

Chemical Property:

• Appearance/Colour: White Crystalline Solid
• Vapor Pressure: 3.51E-12mmHg at 25°C
• Melting Point: 177 °C
• Refractive Index: n20/D 1.367
• Boiling Point: 519.4 °C at 760 mmHg
• PKA: 7.66(at 25℃)
• Flash Point: 267.9 °C
• PSA: 125.49000
• Density: 1.041 g/mL at 25 °C
• LogP: 1.69440
• Storage Temp.: 2-8°C
• Sensitive.: Moisture Sensitive
• Solubility.: H2O: 50 mg/mL
• Water Solubility.: Soluble in water and methanol.
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 9
• Exact Mass: 286.0373029
• Heavy Atom Count: 17
• Complexity: 222

Purity/Quality:

99% ^*data from raw suppliers

TCEPHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: C,Xi
• Statements: 36/38-36/37/38-34
• Safety Statements: 26-37/39-36/37/39-27-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(CP(CCC(=O)O)CCC(=O)O)C(=O)O.Cl
• Description: TCEP HCl (51805-45-9) is a reagent for selective reduction of disulfides in aqueous solutions1-3?with distinct advantages over DTT which are application specific3. For example, spin labels are more stable with TCEP than DTT, Ni2+?(leached from affinity columns) causes rapid oxidation of DTT with no effect on TCEP and for long term storage of proteins TCEP is more stable than DTT with no metal chelator (EGTA) present but DTT is more stable in the presence of metal chelators.3
• Uses: TCEP (Tris(2-carboxyethyl)phosphine hydrochloride) is an alternative which is not pungent, more stable and works even at low pH. It is more selective, i.e. do not reduce metals and buried disulfides. Biochemical tool for selective reduction of disulfide bridges at low pH; reductant for redox assays. Reducing agent, specific for disulfidesTris(2-carboxyethyl)phosphine hydrochloride is widely used as a reducing agent to reduce disulfide bonds in proteins and trans-4,5-dihydroxy-1,2-dithiane. It is involved in the reduction of sulfoxides, sulfonyl chlorides, N-oxides, and azides. It plays an important role in the tissue homogenization process for RNA isolation. It acts as a chelating agent and forms complexes with various heavy metal ions such as Zn(II), Cd(II), Pb(II), and Ni(II). Furthermore, it is useful in the labeling of cysteine residues with maleimides.