4-{2-amino-4-[4-fluoro-3-(2-fluoropyridin-3-yl)phenyI]-5-oxo-4,5-dihydro-1H-imidazol-4-yI}phenyI methanesulfonate

Base Information

Chemical Name:4-{2-amino-4-[4-fluoro-3-(2-fluoropyridin-3-yl)phenyI]-5-oxo-4,5-dihydro-1H-imidazol-4-yI}phenyI methanesulfonate
CAS No.:937595-45-4
Molecular Formula:C₂₂H₁₈F₂N₄O₄S
Molecular Weight:472.472
Hs Code.:

Synonyms:4-{2-amino-4-[4-fluoro-3-(2-fluoropyridin-3-yl)phenyI]-5-oxo-4,5-dihydro-1H-imidazol-4-yI}phenyI methanesulfonate

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Chemical Property of 4-{2-amino-4-[4-fluoro-3-(2-fluoropyridin-3-yl)phenyI]-5-oxo-4,5-dihydro-1H-imidazol-4-yI}phenyI methanesulfonate

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Technology Process of 4-{2-amino-4-[4-fluoro-3-(2-fluoropyridin-3-yl)phenyI]-5-oxo-4,5-dihydro-1H-imidazol-4-yI}phenyI methanesulfonate

There total 1 articles about 4-{2-amino-4-[4-fluoro-3-(2-fluoropyridin-3-yl)phenyI]-5-oxo-4,5-dihydro-1H-imidazol-4-yI}phenyI methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 4-[2-amino-4-(3-bromo-4-fluorophenyl)-1-methyl-5-oxo-4,5-dihydro-1H-imidazol-4-yl]phenyl methanesulfonate

: 174669-73-9
(2-fluoro-pyridin-3-yl)boronic acid

: 937595-45-4
4-{2-amino-4-[4-fluoro-3-(2-fluoropyridin-3-yl)phenyI]-5-oxo-4,5-dihydro-1H-imidazol-4-yI}phenyI methanesulfonate

Guidance literature:: With potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; at 130 ℃; for 3h; Irradiation in a microwave;

Reference yield:

: 937595-45-4
4-{2-amino-4-[4-fluoro-3-(2-fluoropyridin-3-yl)phenyI]-5-oxo-4,5-dihydro-1H-imidazol-4-yI}phenyI methanesulfonate

: 1035266-96-6
(R) 4-{2-amino-4-[4-fluoro-3-(2-fluoropyridin-3-yl)phenyI]-5-oxo-4,5-dihydro-1H-imidazol-4-yI}phenyI methanesulfonate

: 1035266-97-7
(S) 4-{2-amino-4-[4-fluoro-3-(2-fluoropyridin-3-yl)phenyI]-5-oxo-4,5-dihydro-1H-imidazol-4-yI}phenyI methanesulfonate

Guidance literature:: 4-{2-amino-4-[4-fluoro-3-(2-fluoropyridin-3-yl)phenyI]-5-oxo-4,5-dihydro-1H-imidazol-4-yI}phenyI methanesulfonate; With diethylamine; In methanol; carbon dioxide; Resolution of racemate;

With hydrogenchloride; In methanol; diethyl ether; carbon dioxide; at 20 ℃; for 0.0833333h; Purification / work up;