4-Benzylnicotinonitrile

Base Information

• Chemical Name: 4-Benzylnicotinonitrile
• CAS No.: 67839-63-8
• Molecular Formula: C₁₃H₁₀N₂
• Molecular Weight: 194.236
• Mol file: 67839-63-8.mol

Synonyms:4-benzylpyridine-3-carbonitrile

Chemical Property of 4-Benzylnicotinonitrile

Chemical Property:

• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

4-Benzylnicotinonitrile 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Benzylnicotinonitrile

There total 6 articles about 4-Benzylnicotinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

4-benzyl-2,6-dichloronicotinonitrile (183118-96-9) → 4-benzylpyridine-3-carbonitrile (67839-63-8)

Guidance literature:

With hydrogen; sodium acetate; palladium on activated charcoal; In methanol; under 760 Torr; Ambient temperature;

Reference yield:

ethyl 3-oxo-4-phenylbutyrate (718-08-1) → 4-benzylpyridine-3-carbonitrile (67839-63-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 45 percent / KOH / ethanol / 24 h / Heating

2: 91 percent / POCl₃, Et₃N / 17 h / 140 °C

3: 75 percent / H₂, NaOAc / 5percent Pd/C / methanol / 760 Torr / Ambient temperature

With potassium hydroxide; hydrogen; sodium acetate; triethylamine; trichlorophosphate; palladium on activated charcoal; In methanol; ethanol;

Reference yield:

4-benzyl-2,6-dihydroxynicotinonitrile (183118-95-8) → 4-benzylpyridine-3-carbonitrile (67839-63-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / POCl₃, Et₃N / 17 h / 140 °C

2: 75 percent / H₂, NaOAc / 5percent Pd/C / methanol / 760 Torr / Ambient temperature

With hydrogen; sodium acetate; triethylamine; trichlorophosphate; palladium on activated charcoal; In methanol;

upstream raw materials:

pyridine-3-carbonitrile

phenylacetic acid

benzyl bromide

3-Cyano-1-ethoxycarbonyl-pyridinium; chloride

Downstream raw materials:

Ethyl 4-benzylpyridine-3-carboxylate