Acetic acid (2R,3R,4S,5S,6R)-4,5-diacetoxy-6-acetoxymethyl-2-[(2R,3R,4R,5S,6R)-3-acetylamino-6-benzyloxymethyl-5-hydroxy-2-(4-methoxy-benzyloxy)-tetrahydro-pyran-4-yloxy]-tetrahydro-pyran-3-yl ester

Base Information

• Chemical Name: Acetic acid (2R,3R,4S,5S,6R)-4,5-diacetoxy-6-acetoxymethyl-2-[(2R,3R,4R,5S,6R)-3-acetylamino-6-benzyloxymethyl-5-hydroxy-2-(4-methoxy-benzyloxy)-tetrahydro-pyran-4-yloxy]-tetrahydro-pyran-3-yl ester
• CAS No.: 161068-38-8
• Molecular Formula: C₃₇H₄₇NO₁₆
• Molecular Weight: 761.777
• Mol file: 161068-38-8.mol

Synonyms:Acetic acid (2R,3R,4S,5S,6R)-4,5-diacetoxy-6-acetoxymethyl-2-[(2R,3R,4R,5S,6R)-3-acetylamino-6-benzyloxymethyl-5-hydroxy-2-(4-methoxy-benzyloxy)-tetrahydro-pyran-4-yloxy]-tetrahydro-pyran-3-yl ester

Chemical Property of Acetic acid (2R,3R,4S,5S,6R)-4,5-diacetoxy-6-acetoxymethyl-2-[(2R,3R,4R,5S,6R)-3-acetylamino-6-benzyloxymethyl-5-hydroxy-2-(4-methoxy-benzyloxy)-tetrahydro-pyran-4-yloxy]-tetrahydro-pyran-3-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Acetic acid (2R,3R,4S,5S,6R)-4,5-diacetoxy-6-acetoxymethyl-2-[(2R,3R,4R,5S,6R)-3-acetylamino-6-benzyloxymethyl-5-hydroxy-2-(4-methoxy-benzyloxy)-tetrahydro-pyran-4-yloxy]-tetrahydro-pyran-3-yl ester

There total 1 articles about Acetic acid (2R,3R,4S,5S,6R)-4,5-diacetoxy-6-acetoxymethyl-2-[(2R,3R,4R,5S,6R)-3-acetylamino-6-benzyloxymethyl-5-hydroxy-2-(4-methoxy-benzyloxy)-tetrahydro-pyran-4-yloxy]-tetrahydro-pyran-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

Acetic acid (2R,3R,4S,5S,6R)-4,5-diacetoxy-6-acetoxymethyl-2-[(4aR,6R,7R,8R,8aS)-7-acetylamino-6-(4-methoxy-benzyloxy)-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yloxy]-tetrahydro-pyran-3-yl ester (153093-15-3) → Acetic acid (2R,3R,4S,5S,6R)-4,5-diacetoxy-6-acetoxymethyl-2-[(2R,3R,4R,5S,6R)-3-acetylamino-6-benzyloxymethyl-5-hydroxy-2-(4-methoxy-benzyloxy)-tetrahydro-pyran-4-yloxy]-tetrahydro-pyran-3-yl ester (161068-38-8)

Guidance literature:

With hydrogenchloride; sodium cyanoborohydride; In tetrahydrofuran; at 0 ℃; for 2h;

DOI:10.1016/S0040-4039(00)78500-5

Reference yield: 89.0%

perbenzyl fucosyl bromide (33639-77-9) + Acetic acid (2R,3R,4S,5S,6R)-4,5-diacetoxy-6-acetoxymethyl-2-[(2R,3R,4R,5S,6R)-3-acetylamino-6-benzyloxymethyl-5-hydroxy-2-(4-methoxy-benzyloxy)-tetrahydro-pyran-4-yloxy]-tetrahydro-pyran-3-yl ester (161068-38-8) → C64H75NO20

Guidance literature:

With tetrabutylammomium bromide; In dichloromethane; N,N-dimethyl-formamide; for 18h; Ambient temperature;

DOI:10.1016/S0040-4039(00)78500-5

Reference yield:

Acetic acid (2R,3R,4S,5S,6R)-4,5-diacetoxy-6-acetoxymethyl-2-[(2R,3R,4R,5S,6R)-3-acetylamino-6-benzyloxymethyl-5-hydroxy-2-(4-methoxy-benzyloxy)-tetrahydro-pyran-4-yloxy]-tetrahydro-pyran-3-yl ester (161068-38-8) → N-[(2R,3R,4R,5S,6R)-6-Benzyloxymethyl-2-(4-methoxy-benzyloxy)-4-((2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-5-((2S,3S,4R,5R,6S)-3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-3-yl]-acetamide

Guidance literature:

Multi-step reaction with 2 steps

1: 89 percent / Bu₄NBr / CH₂Cl₂; dimethylformamide / 18 h / Ambient temperature

2: 99 percent / NEt₃ / methanol; H₂O / 20 h / Ambient temperature

With tetrabutylammomium bromide; triethylamine; In methanol; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(00)78500-5

upstream raw materials:

Acetic acid (2R,3R,4S,5S,6R)-4,5-diacetoxy-6-acetoxymethyl-2-[(4aR,6R,7R,8R,8aS)-7-acetylamino-6-(4-methoxy-benzyloxy)-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yloxy]-tetrahydro-pyran-3-yl ester